Clozapine

Contraindicated

Clozapine Ketoconazole Topical Extina® Foam Increased cloZAPine exposure and an increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Clozapine Metoclopramide Injection Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Clozapine Metoclopramide Nasal Spray Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details

Major

Clozapine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Clozapine Abametapir Explained Increased exposure of CYP1A2 substrates Details Clozapine Amitriptyline Elavil Explained An increased risk of anticholinergic toxicity, gastrointestinal adverse reactions, and an increased risk of QT interval prolongati... Details Clozapine Sertraline Explained Increased clozapine exposure and risk of QT prolongation Details Clozapine Buprenorphine Belbuca Explained An increased risk of QT interval prolongation, an increased risk of CNS and respiratory depression and an increased risk of paraly... Details Clozapine Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Clozapine Trospium / Xanomeline Cobenfy Explained Increased risk of anticholinergic toxicity and gastrointestinal adverse reactions Details Clozapine Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Clozapine Arsenic Trioxide Trisenox Increased risk of QT interval prolongation Details Clozapine Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Clozapine Arsenic Trioxide Injection Trisenox Increased risk of QT interval prolongation Details Clozapine Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Clozapine Azithromycin AzaSite Increased risk of QT interval prolongation Details Clozapine Cabergoline Dostinex® Reduced efficacy of cabergoline and reduced efficacy of dopamine-2 receptors Details Clozapine Abiraterone Abirtega Increased clozapine exposure Details Clozapine Aclidinium Oral Inhalation Tudorza Increased risk of anticholinergic toxicity and gastrointestinal adverse reactions Details Clozapine Alfuzosin UroXatral Increased risk of QT interval prolongation Details Clozapine Anagrelide Agrylin Increased risk of QT interval prolongation Details Clozapine Atropine Ophthalmic Atropine Care 1% Increased risk of anticholinergic toxicity and gastrointestinal adverse reactions Details Clozapine Bedaquiline Sirturo Increased risk of QT interval prolongation Details Clozapine Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Clozapine Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Clozapine Capmatinib Tabrecta Increased CYP1A2 substrate exposure and an increased risk of adverse reactions Details Clozapine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Clozapine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Clozapine Chloroquine Aralen® Increased risk of QT interval prolongation Details Clozapine Cyclopentolate Ophthalmic Akpentolate® Increased risk of anticholinergic toxicity and gastrointestinal adverse reactions Details Clozapine Cyclosporine Injection Atopica Increased cloZAPine exposure Details Clozapine Cyclosporine Ophthalmic Cequa Increased cloZAPine exposure Details Clozapine Dasatinib Phyrago An increased risk of QT interval prolongation Details Clozapine Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Clozapine Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Clozapine Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Clozapine Diazepam Rectal Diastat Increased risk of CNS depression Details Clozapine Diphenhydramine Injection Banophen Increased risk of anticholinergic toxicity and gastrointestinal adverse reactions Details Clozapine Diphenhydramine Topical Afterbite with Antihistamine Increased risk of anticholinergic toxicity and gastrointestinal adverse reactions Details Clozapine Disopyramide Norpace Increased risk of QT interval prolongation Details