Cyclobenzaprine

97 interactions 6 explained in plain English

Also sold as: Amrix Fexmid Tonmya

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Linezolid Injection Gatifloxacin Ophthalmic Amitriptyline Palonosetron Injection Fentanyl Transdermal Patch Foscarnet Injection

1 Contraindicated 95 Major 1 Moderate

All (97) Contraindicated (1) Major (95) Moderate (1)

Major

Cyclobenzaprine Felbamate Felbatol An increased risk of QT interval prolongation Details Cyclobenzaprine Fentanyl Transdermal Patch Duragesic® Increased risk of serotonin syndrome, an increased risk of CNS depression, an increased degree of respiratory depression and an in... Details Cyclobenzaprine Flecainide Tambocor® An increased risk of QT interval prolongation Details Cyclobenzaprine Foscarnet Injection Foscavir Increased risk of QT interval prolongation Details Cyclobenzaprine Fostemsavir Rukobia Increased risk of torsade de pointes Details Cyclobenzaprine Galantamine Razadyne An increased risk of QT interval prolongation Details Cyclobenzaprine Gatifloxacin Ophthalmic Zymar® An increased risk of QT interval prolongation Details Cyclobenzaprine Gemifloxacin Factive An increased risk of QT interval prolongation Details Cyclobenzaprine Glasdegib Daurismo Increased risk of QT interval prolongation Details Cyclobenzaprine Glucagon Injection Baqsimi Increased risk of gastrointestinal side effects Details Cyclobenzaprine Glucagon Injection / Solution Baqsimi Increased risk of gastrointestinal side effects Details Cyclobenzaprine Glucagon Nasal Powder Baqsimi Increased risk of gastrointestinal side effects Details Cyclobenzaprine Glycopyrronium Topical Cuvposa® An increased risk of anticholinergic side effects Details Cyclobenzaprine Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Cyclobenzaprine Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome and QT-interval prolongation Details Cyclobenzaprine Granisetron Injection Granisol Increased risk of serotonin syndrome and QT-interval prolongation Details Cyclobenzaprine Histrelin Implant Supprelin Increased risk of QT interval prolongation Details Cyclobenzaprine Hydromorphone Injection Dilaudid Increased risk of paralytic ileus, an increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Cyclobenzaprine Hydromorphone Rectal available generically Increased risk of paralytic ileus, an increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Cyclobenzaprine Hydroxychloroquine Plaquenil Increased risk of QT interval prolongation Details Cyclobenzaprine Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Cyclobenzaprine Ipratropium Nasal Spray Atrovent Nasal Spray® An increased risk of atropine-like adverse reactions Details Cyclobenzaprine Ipratropium Oral Inhalation Atrovent® HFA An increased risk of atropine-like adverse reactions Details Cyclobenzaprine Ivabradine Corlanor Increased risk of QT prolongation Details Cyclobenzaprine Ketoconazole Topical Extina® Foam An increased risk of QT interval prolongation Details Cyclobenzaprine Lacosamide Injection Motpoly An increased risk of CNS depression Details Cyclobenzaprine Lefamulin Xenleta Increased risk of QT interval prolongation Details Cyclobenzaprine Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Cyclobenzaprine Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Cyclobenzaprine Levofloxacin Levaquin An increased risk of QT interval prolongation Details Cyclobenzaprine Levofloxacin Injection Levaquin An increased risk of QT interval prolongation Details Cyclobenzaprine Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Cyclobenzaprine Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Cyclobenzaprine Mefloquine Lariam® An increased risk of QT interval prolongation Details Cyclobenzaprine Metoclopramide Injection Gimoti Increased risk of CNS depression Details Cyclobenzaprine Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Cyclobenzaprine Metronidazole Flagyl An increased risk of QT interval prolongation Details Cyclobenzaprine Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Cyclobenzaprine Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Cyclobenzaprine Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.