Cyclobenzaprine
97 interactions 6 explained in plain English
Also sold as:
Amrix
Fexmid
Tonmya
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
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Contraindicated
Cyclobenzaprine Linezolid Injection Zyvox Increased risk of serotonin syndrome and an increased risk of hyperpyretic crisis seizures DetailsMajor
Cyclobenzaprine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of paralytic ileus; increased risk of respiratory and CNS depression; increased risk of serotonin syndrome Details Cyclobenzaprine Amitriptyline Elavil Explained An increased risk of atropine-like adverse reactions, an increased risk of serotonin syndrome and an increased risk of QT interval... Details Cyclobenzaprine Sertraline Explained Increased risk of serotonin syndrome and an increased risk of QT interval prolongation Details Cyclobenzaprine Buprenorphine Belbuca Explained An increased risk of serotonin syndrome, an increased risk of QT interval prolongation, an increased risk of CNS and respiratory d... Details Cyclobenzaprine Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Cyclobenzaprine Trospium / Xanomeline Cobenfy Explained An increased risk of atropine-like adverse reactions Details Cyclobenzaprine Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Cyclobenzaprine Arsenic Trioxide Trisenox An increased risk of QT interval prolongation Details Cyclobenzaprine Aripiprazole Injection Abilify An increased risk of CNS depression, somnolence or sedation and an increased risk of QT interval prolongation Details Cyclobenzaprine Arsenic Trioxide Injection Trisenox An increased risk of QT interval prolongation Details Cyclobenzaprine Asenapine Transdermal Patch Secuado An increased risk of CNS depression and an increased risk of QT interval prolongation Details Cyclobenzaprine Azithromycin AzaSite An increased risk of QT interval prolongation and torsade de pointes Details Cyclobenzaprine Aclidinium Oral Inhalation Tudorza An increased risk of atropine-like adverse reactions Details Cyclobenzaprine Alfuzosin UroXatral An increased risk of QT interval prolongation Details Cyclobenzaprine Anagrelide Agrylin Increased risk of QT interval prolongation Details Cyclobenzaprine Atropine Ophthalmic Atropine Care 1% An increased risk of atropine-like adverse reactions Details Cyclobenzaprine Bedaquiline Sirturo Increased risk of QT interval prolongation Details Cyclobenzaprine Butorphanol Injection Butorphic Increased risk of serotonin syndrome and an increased risk of CNS depression Details Cyclobenzaprine Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome and an increased risk of CNS depression Details Cyclobenzaprine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Cyclobenzaprine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Cyclobenzaprine Chloroquine Aralen® Increased risk of QT-interval prolongation Details Cyclobenzaprine Cyclopentolate Ophthalmic Akpentolate® An increased risk of atropine-like adverse reactions Details Cyclobenzaprine Dasatinib Phyrago An increased risk of QT interval prolongation Details Cyclobenzaprine Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Cyclobenzaprine Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Cyclobenzaprine Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Cyclobenzaprine Diazepam Rectal Diastat Increased risk of CNS depression Details Cyclobenzaprine Diphenhydramine Injection Banophen An increased risk of atropine-like adverse reactions and an increased risk of CNS depression Details Cyclobenzaprine Diphenhydramine Topical Afterbite with Antihistamine An increased risk of atropine-like adverse reactions and an increased risk of CNS depression Details Cyclobenzaprine Disopyramide Norpace An increased risk of QT interval prolongation Details Cyclobenzaprine Dofetilide Tikosyn An increased risk of QT interval prolongation Details Cyclobenzaprine Dolasetron Anzemet Increased risk of serotonin syndrome and QT-interval prolongation Details Cyclobenzaprine Dolasetron Injection Anzemet Increased risk of serotonin syndrome and QT-interval prolongation Details Cyclobenzaprine Encorafenib Braftovi Increased risk of QT interval prolongation Details Cyclobenzaprine Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Cyclobenzaprine Eribulin Injection Halaven An increased risk of QT interval prolongation Details Cyclobenzaprine Esketamine Nasal Spray Spravato Increased risk of sedation Details Cyclobenzaprine Famotidine Calmicid An increased risk of QT interval prolongation DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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