Cyclobenzaprine

97 interactions 6 explained in plain English
Also sold as: Amrix Fexmid Tonmya
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Linezolid Injection Gatifloxacin Ophthalmic Amitriptyline Palonosetron Injection Fentanyl Transdermal Patch Foscarnet Injection
1 Contraindicated 95 Major 1 Moderate
All (97) Contraindicated (1) Major (95) Moderate (1)

Major

Cyclobenzaprine Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Cyclobenzaprine Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Cyclobenzaprine Morphine Injection Astramorph® PF Increased risk of respiratory and CNS depression, increased risk of serotonin syndrome and an increased risk of urinary retention,... Details Cyclobenzaprine Moxifloxacin Avelox An increased risk of QT interval prolongation Details Cyclobenzaprine Moxifloxacin Injection Avelox An increased risk of QT interval prolongation Details Cyclobenzaprine Moxifloxacin Ophthalmic Moxeza® An increased risk of QT interval prolongation Details Cyclobenzaprine Nalbuphine Injection Nubain® Increased risk of serotonin syndrome and an increased risk of CNS depression Details Cyclobenzaprine Octreotide Bynfezia An increased risk of QT interval prolongation Details Cyclobenzaprine Octreotide Injection Bynfezia An increased risk of QT interval prolongation Details Cyclobenzaprine Ofloxacin Floxin® An increased risk of QT interval prolongation Details Cyclobenzaprine Ofloxacin Ophthalmic Ocuflox An increased risk of QT interval prolongation Details Cyclobenzaprine Ofloxacin Otic Floxin® Otic An increased risk of QT interval prolongation Details Cyclobenzaprine Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Cyclobenzaprine Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details Cyclobenzaprine Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.