Drug Interaction Report

Cyclopentolate Ophthalmic and Secretin Human: Interaction Details

Name: Cyclopentolate Ophthalmic and Secretin Human Interaction
Creator: Dr. Brian Staiger, PharmD, BCPS

A pharmacist-reviewed analysis of the Cyclopentolate Ophthalmic and Secretin Human interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Cyclopentolate Ophthalmic

Akpentolate® Cyclogyl Cyclogyl® Cyclomydril® (as a combination product containing Cyclopentolate, Phenylephrine) Cylate Pentolair®

Secretin Human

Chirhostim

Medically reviewed by

Dr. Brian Staiger, PharmD, BCPS

Updated Aug 8, 2026

Editorial policy · Data sources

Interaction severity

Major

Potentially serious — often needs a change or close monitoring.

Minor

Moderate

Major

Contraindicated

How we grade severity & evidence

Severity levels

Contraindicated: These should generally not be used together.
Major: Potentially serious — often needs a change or close monitoring.
Moderate: Can be significant — usually manageable with monitoring.
Minor: Usually limited clinical impact.

Evidence grades

Established: Well documented — supported by controlled studies or strong clinical data.
Probable: Good supporting evidence, though not definitively proven.
Suspected: Some evidence suggests this interaction, but it is not well established.
Possible: Limited or conflicting evidence; the interaction may occur.
Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 46 documented Cyclopentolate Ophthalmic interactions, 39 are rated major — including this one.

Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.

Onset

unspecified

Evidence

theoretical

Severity

Major

What happens

False positive stimulation test results with secretin human

Interaction Deep Dive

Concomitant use of anticholinergic drugs may cause a hyporesponse to secretin stimulation resulting in a false positive test for pancreatic disease. Discontinue anticholinergic drugs at least 5 half-lives before administering secretin human and consider additional testing and clinical assessments for aid in diagnosis¹.

Why it happens (mechanism)

Hyporesponse to secretin stimulation

Common questions

Can I take Cyclopentolate Ophthalmic and Secretin Human together?

False positive stimulation test results with secretin human Always confirm with your pharmacist or prescriber before making any change.

How serious is the Cyclopentolate Ophthalmic and Secretin Human interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

Does my dose of Cyclopentolate Ophthalmic or Secretin Human need adjusting while I take them together?
What symptoms should prompt me to call you or my prescriber right away?
Does the timing of my doses matter for this combination?
Is there a safer alternative to one of these medications for me?

References (1)

Product Information: CHIRHOSTIM(R) intravenous injection, human secretin intravenous injection. ChiRhoClin, Inc. (per FDA), Burtonsville, MD, 2017. DailyMed

Was this write-up helpful?

Cyclopentolate Ophthalmic

Keep reading about Cyclopentolate Ophthalmic

All Cyclopentolate Ophthalmic interactions (46) Cyclopentolate Ophthalmic drug information

Also serious with: Potassium Citrate Potassium Chloride Alfentanil Amantadine

Secretin Human

Keep reading about Secretin Human

All Secretin Human interactions (18)

Also serious with: Diphenhydramine Topical Amitriptyline Glycopyrronium Topical Nizatidine

Check another combination

Our instant two-drug interaction checker is almost here.

Coming soon

The instant two-drug checker is on its way.

In the meantime, browse the directory below to look up any drug and see its documented interactions.

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

A message from HelloPharmacist

About our interaction database: depth, not breadth

HelloPharmacist doesn't license one of the big commercial interaction databases, so what you'll find here is not a complete list of every known drug interaction. Instead, each entry is researched, analyzed, and written up individually — documented from the published literature, reviewed by a pharmacist, and cited so you can check every source yourself.

If a combination isn't listed here, it means we haven't documented it yet — never that it's safe. For screening a full medication list, we recommend pairing this site with a comprehensive tool like the Drugs.com Interaction Checker and, most importantly, a review by your own pharmacist. For a deep, plain-English, fully sourced explanation of a specific documented interaction — that's exactly what we built this for.

This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.