Cyclopentolate Ophthalmic

46 interactions 115 cited references
Also sold as: Akpentolate® Cyclogyl Cyclogyl® Cyclomydril® (as a combination product containing Cyclopentolate, Phenylephrine) Cylate Pentolair®
About Cyclopentolate Ophthalmic

Cyclopentolate ophthalmic is used to cause mydriasis (pupil dilation) and cycloplegia (paralysis of the ciliary muscle of the eye) before an eye examination. Cyclopentolate is in a class of medications called mydriatics. Cyclopentolate works by blocking certain receptors found in the eye to temporarily relax or provide… Read the full Cyclopentolate Ophthalmic drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Potassium Citrate Potassium Chloride Alfentanil Amantadine Amifampridine Benzhydrocodone
2 Contraindicated 39 Major 2 Moderate 3 Minor
All (46) Contraindicated (2) Major (39) Moderate (2) Minor (3)

Contraindicated

Cyclopentolate Ophthalmic Potassium Chloride K-Tab Increased risk of gastrointestinal irritation Details Cyclopentolate Ophthalmic Potassium Citrate Urocit-K Increased risk of gastrointestinal irritation Details

Major

Cyclopentolate Ophthalmic Alfentanil An increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Details Cyclopentolate Ophthalmic Amantadine Potentiation of anticholinergic effects Details Cyclopentolate Ophthalmic Amifampridine Increased risk of seizures Details Cyclopentolate Ophthalmic Benzhydrocodone Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Cyclopentolate Ophthalmic Buprenorphine Belbuca An increased risk of paralytic ileus Details Cyclopentolate Ophthalmic Bupropion Aplenzin Increased risk of seizures Details Cyclopentolate Ophthalmic Clomipramine Anafranil An increased risk of anticholinergic effects and an increased risk of seizures Details Cyclopentolate Ophthalmic Clozapine Clozaril Increased risk of anticholinergic toxicity and gastrointestinal adverse reactions Details Cyclopentolate Ophthalmic Codeine Tuzistra XR® (as a combination product containing Chlorpheniramine, Codeine) An increased risk of paralytic ileus Details Cyclopentolate Ophthalmic Cyclobenzaprine Amrix An increased risk of atropine-like adverse reactions Details Cyclopentolate Ophthalmic Dihydrocodeine Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Cyclopentolate Ophthalmic Donepezil Adlarity Reduced seizure threshold Details Cyclopentolate Ophthalmic Fentanyl Increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Details Cyclopentolate Ophthalmic Glucagon Increased risk of gastrointestinal side effects Details Cyclopentolate Ophthalmic Glycopyrrolate Cuvposa An increased risk of anticholinergic side effects Details Cyclopentolate Ophthalmic Glycopyrronium Tosylate An increased risk of anticholinergic side effects Details Cyclopentolate Ophthalmic Hydrocodone Hysingla Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Cyclopentolate Ophthalmic Hydromorphone Dilaudid Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Cyclopentolate Ophthalmic Hydroxychloroquine Plaquenil An increased risk of seizures Details Cyclopentolate Ophthalmic Letibotulinumtoxina-Wlbg Letybo Increased neuromuscular weakness and heightened systemic anticholinergic effects Details Cyclopentolate Ophthalmic Meperidine Demerol Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Cyclopentolate Ophthalmic Methacholine Inhibition of the airway response to methacholine Details Cyclopentolate Ophthalmic Methadone Diskets Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Cyclopentolate Ophthalmic Morphine Increased risk of urinary retention, severe constipation, and paralytic ileus Details Cyclopentolate Ophthalmic Morphine Sulfate Liposome Increased risk of urinary retention, severe constipation, and paralytic ileus Details Cyclopentolate Ophthalmic Olanzapine Increased risk of severe gastrointestinal adverse reactions Details Cyclopentolate Ophthalmic Oliceridine Olinvyk Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Cyclopentolate Ophthalmic Oxycodone Oxaydo An increased risk of paralytic ileus Details Cyclopentolate Ophthalmic Oxymorphone Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Cyclopentolate Ophthalmic Promethazine Phenadoz Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Cyclopentolate Ophthalmic Quetiapine Seroquel An increased risk of anticholinergic side effects, including intestinal obstruction Details Cyclopentolate Ophthalmic Revefenacin Yupelri Increased risk of anticholinergic side effects Details Cyclopentolate Ophthalmic Scopolamine Pamine Increased or potentiated scopolamine effects, an increased risk of CNS adverse reactions and an increased risk of intestinal obstr... Details Cyclopentolate Ophthalmic Secretin Human Chirhostim False positive stimulation test results with secretin human Details Cyclopentolate Ophthalmic Sofpironium An increased risk of hyperpyrexia and heat stroke due to decreased sweating Details Cyclopentolate Ophthalmic Sufentanil Dsuvia Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Cyclopentolate Ophthalmic Tapentadol Nucynta An increased risk of paralytic ileus Details Cyclopentolate Ophthalmic Tiotropium An increased risk of anticholinergic side effects Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.