Cyclopentolate Ophthalmic and Quetiapine: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Quetiapine
Cyclopentolate Ophthalmic
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of anticholinergic side effects, including intestinal obstruction
Interaction Deep Dive
NorQUEtiapine, an active metabolite of QUEtiapine, has moderate to strong affinity for several muscarinic receptor subtypes, which contributes to the anticholinergic adverse reactions when QUEtiapine is used concomitantly with other anticholinergic medications. Concomitant use with anticholinergic agents increases the risk for severe gastrointestinal adverse reactions related to hypomotility. Fatalities due to intestinal obstruction have been reported. QUEtiapine should be used with caution in patients receiving other anticholinergic (antimuscarinic) agents2. Concomitant administration of glycopyrrolate and other anticholinergics like QUEtiapine may increase the risk of additive anticholinergic effects 1.
Why it happens (mechanism)
Additive anticholinergic effects caused by norQUEtiapine, an active metabolite of QUEtiapine
Literature reports
1 report — tap to read
a) Intestinal obstruction, including fatalities has been reported with the concomitant use of QUEtiapine and multiple concomitant medications that decrease intestinal motility 2.
Common questions
Can I take Cyclopentolate Ophthalmic and Quetiapine together?
An increased risk of anticholinergic side effects, including intestinal obstruction Always confirm with your pharmacist or prescriber before making any change.
How serious is the Cyclopentolate Ophthalmic and Quetiapine interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Cyclopentolate Ophthalmic or Quetiapine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: PREVDUO intravenous injection, neostigmine methylsulfate glycopyrrolate intravenous injection. Slayback Pharma LLC (per FDA), Princeton, NJ, 2023. DailyMed
- Product Information: SEROQUEL(R) oral tablets, quetiapine oral tablets. AstraZeneca Pharmaceuticals LP (per FDA), Wilmington, DE, 2020. DailyMed
Keep reading about Quetiapine
Keep reading about Cyclopentolate Ophthalmic
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
Check another combination
Our instant two-drug interaction checker is almost here.
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacist