Quetiapine

98 interactions 6 explained in plain English

Also sold as: Seroquel

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Metoclopramide Injection Ketoconazole Topical Lefamulin Metoclopramide Nasal Spray Oxaliplatin Injection Dofetilide

4 Contraindicated 92 Major 2 Moderate

All (98) Contraindicated (4) Major (92) Moderate (2)

Contraindicated

Quetiapine Ketoconazole Topical Extina® Foam Increased QUEtiapine exposure and an increased risk of QT interval prolongation Details Quetiapine Lefamulin Xenleta Increased sensitive CYP3A4 substrates exposure and an increased risk of QT interval prolongation Details Quetiapine Metoclopramide Injection Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Quetiapine Metoclopramide Nasal Spray Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details

Major

Quetiapine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Quetiapine Amitriptyline Elavil Explained An increased risk of QT interval prolongation Details Quetiapine Sertraline Explained An increased risk of QT interval prolongation Details Quetiapine Buprenorphine Belbuca Explained An increased risk of QT interval prolongation, an increased risk of CNS and respiratory depression and an increased risk of paraly... Details Quetiapine Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Quetiapine Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Quetiapine Arsenic Trioxide Trisenox Prolongation of the QTc interval and/or torsades de pointes Details Quetiapine Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Quetiapine Arsenic Trioxide Injection Trisenox Prolongation of the QTc interval and/or torsades de pointes Details Quetiapine Asenapine Transdermal Patch Secuado An increased risk of QT interval prolongation Details Quetiapine Azithromycin AzaSite An increased risk of QT interval prolongation Details Quetiapine Cabergoline Dostinex® Reduced efficacy of cabergoline and reduced efficacy of dopamine-2 receptors Details Quetiapine Aclidinium Oral Inhalation Tudorza An increased risk of anticholinergic side effects, including intestinal obstruction Details Quetiapine Alfuzosin UroXatral An increased risk of QT interval prolongation Details Quetiapine Anagrelide Agrylin An increased risk of QT interval prolongation Details Quetiapine Atropine Ophthalmic Atropine Care 1% An increased risk of anticholinergic side effects, including intestinal obstruction Details Quetiapine Bedaquiline Sirturo An increased risk of QT interval prolongation Details Quetiapine Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Quetiapine Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Quetiapine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Quetiapine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Quetiapine Chloroquine Aralen® An increased risk of QT interval prolongation Details Quetiapine Cyclopentolate Ophthalmic Akpentolate® An increased risk of anticholinergic side effects, including intestinal obstruction Details Quetiapine Dasatinib Phyrago An increased risk of QT interval prolongation Details Quetiapine Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Quetiapine Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Quetiapine Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Quetiapine Diazepam Rectal Diastat Increased risk of CNS depression Details Quetiapine Diphenhydramine Injection Banophen An increased risk of anticholinergic side effects, including intestinal obstruction Details Quetiapine Diphenhydramine Topical Afterbite with Antihistamine An increased risk of anticholinergic side effects, including intestinal obstruction Details Quetiapine Disopyramide Norpace An increased risk of QT interval prolongation Details Quetiapine Dofetilide Tikosyn An increased risk of QT interval prolongation Details Quetiapine Dolasetron Anzemet An increased risk of QT interval prolongation Details Quetiapine Dolasetron Injection Anzemet An increased risk of QT interval prolongation Details Quetiapine Encorafenib Braftovi Reduced CYP3A4 substrate exposure, reduced efficacy of CYP3A4 substrate and an increased risk of QT interval prolongation Details Quetiapine Entrectinib Rozlytrek An increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.