Cyclopentolate Ophthalmic and Xanomeline: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Cyclopentolate Ophthalmic
Xanomeline
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of anticholinergic adverse reactions (eg, dry mouth, constipation)
Interaction Deep Dive
Concomitant use of xanomeline/trospium chloride with antimuscarinic drugs that produce anticholinergic adverse reactions (eg, dry mouth, constipation) may increase the frequency and/or severity of such effects. If coadministered, monitor patients for increased frequency and/or severity of anticholinergic adverse reactions1.
Why it happens (mechanism)
Additive antimuscarinic effects
Common questions
Can I take Cyclopentolate Ophthalmic and Xanomeline together?
An increased risk of anticholinergic adverse reactions (eg, dry mouth, constipation) Always confirm with your pharmacist or prescriber before making any change.
How serious is the Cyclopentolate Ophthalmic and Xanomeline interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Cyclopentolate Ophthalmic or Xanomeline need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Product Information: COBENFY(TM) oral capsules, xanomeline, trospium chloride oral capsules. Bristol-Myers Squibb Company (Per FDA), Princeton, NJ, 2024. DailyMed
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