Cyproheptadine
30 interactions 2 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Linezolid Injection
Buprenorphine
Methotrexate Injection
Fentanyl Transdermal Patch
Nalbuphine Injection
Hydromorphone Rectal
Contraindicated
Cyproheptadine Linezolid Injection Zyvox Prolonged and intensified anticholinergic effects and an increased cyproheptadine effects DetailsMajor
Cyproheptadine Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of paralytic ileus and an increased risk of CNS depression Details Cyproheptadine Buprenorphine Belbuca Explained An increased risk of paralytic ileus and an increased risk of CNS depression Details Cyproheptadine Aripiprazole Injection Abilify An increased risk of CNS depression Details Cyproheptadine Asenapine Transdermal Patch Secuado An increased risk of CNS depression Details Cyproheptadine Azathioprine Azasan An increased risk of hepatotoxicity Details Cyproheptadine Butorphanol Injection Butorphic An increased risk of CNS depression Details Cyproheptadine Butorphanol Nasal Spray Stadol® NS An increased risk of CNS depression Details Cyproheptadine Cetirizine Injection Aller-Tec An increased risk of CNS depression Details Cyproheptadine Cetirizine Ophthalmic Zerviate An increased risk of CNS depression Details Cyproheptadine Diazepam Nasal Spray Valtoco An increased risk of CNS depression Details Cyproheptadine Diazepam Rectal Diastat An increased risk of CNS depression Details Cyproheptadine Diphenhydramine Injection Banophen An increased risk of CNS depression Details Cyproheptadine Diphenhydramine Topical Afterbite with Antihistamine An increased risk of CNS depression Details Cyproheptadine Esketamine Nasal Spray Spravato An increased risk of CNS depression Details Cyproheptadine Fentanyl Transdermal Patch Duragesic® Increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus and an increased risk of CNS dep... Details Cyproheptadine Glucagon Injection Baqsimi Increased risk of gastrointestinal side effects Details Cyproheptadine Glucagon Injection / Solution Baqsimi Increased risk of gastrointestinal side effects Details Cyproheptadine Glucagon Nasal Powder Baqsimi Increased risk of gastrointestinal side effects Details Cyproheptadine Glycopyrronium Topical Cuvposa® An increased risk of anticholinergic side effects Details Cyproheptadine Hydromorphone Injection Dilaudid Increased risk of urinary retention and/or severe constipation leading to paralytic ileus and an increased risk of CNS depression Details Cyproheptadine Hydromorphone Rectal available generically Increased risk of urinary retention and/or severe constipation leading to paralytic ileus and an increased risk of CNS depression Details Cyproheptadine Hydroxychloroquine Plaquenil An increased risk of seizures Details Cyproheptadine Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Cyproheptadine Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Cyproheptadine Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Cyproheptadine Midazolam Nasal Spray Nayzilam An increased risk of CNS depression Details Cyproheptadine Midazolam Injection Nayzilam An increased risk of CNS depression Details Cyproheptadine Morphine Injection Astramorph® PF Increased risk of urinary retention, severe constipation, and paralytic ileus and an increased risk of CNS depression Details Cyproheptadine Nalbuphine Injection Nubain® An increased risk of CNS depression DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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