Daclatasvir and Dexamethasone Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Daclatasvir
Dexamethasone Injection
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Decreased daclatasvir exposure and risk of loss of daclatasvir efficacy
Interaction Deep Dive
Use caution when coadministering daclatasvir and a moderate CYP3A4 inducer as this may result in decreased plasma concentrations of daclatasvir and a decrease in daclatasvir efficacy. If concomitant use is required, increase the daclatasvir dose to 90 mg once daily1 and consider monitoring for reduced efficacy.
Why it happens (mechanism)
Induction of CYP3A4-mediated daclatasvir metabolism
Common questions
Can I take Daclatasvir and Dexamethasone Injection together?
Decreased daclatasvir exposure and risk of loss of daclatasvir efficacy Always confirm with your pharmacist or prescriber before making any change.
How serious is the Daclatasvir and Dexamethasone Injection interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Daclatasvir or Dexamethasone Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: DAKLINZA(TM) oral tablets, daclatasvir oral tablets. Bristol-Myers Squibb (per manufacturer), Princeton, NJ, 2015.
Keep reading about Daclatasvir
Keep reading about Dexamethasone Injection
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