Dalfampridine

Name: Dalfampridine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

11 interactions 73 cited references

Also sold as: Ampyra Ampyra®

About Dalfampridine

Dalfampridine is used to improve walking in people who have multiple sclerosis (MS; a disease in which the nerves do not function properly and may cause weakness, numbness, loss of muscle coordination, and problems with vision, speech, and bladder control). Dalfampridine may be used alone or with other medications that… Read the full Dalfampridine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Arimoclomol Bictegravir Bupropion Clomipramine Dolutegravir Fedratinib

11 Major

All (11) Major (11)

Major

Dalfampridine Arimoclomol Increased OCT2 substrate exposure Details Dalfampridine Bictegravir Increased dalfampridine exposure Details Dalfampridine Bupropion Aplenzin Increased risk of seizures Details Dalfampridine Clomipramine Anafranil Increased risk of seizures Details Dalfampridine Dolutegravir Juluca® (as a combination product containing dolutegravir, rilpivirine) Increased dalfampridine exposure and an increased risk of seizures Details Dalfampridine Fedratinib Inrebic Increased dalfampridine exposure and an increased risk of dalfampridine-related adverse events Details Dalfampridine Fexinidazole Increased dalfampridine exposure Details Dalfampridine Hydroxychloroquine Plaquenil An increased risk of seizures Details Dalfampridine Tramadol ConZip An increased risk of seizure Details Dalfampridine Trilaciclib Increased plasma concentrations of dalfampridine Details Dalfampridine Vimseltinib Romvimza Increased risk of OCT2 substrate exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.