Dalfopristin and Diazepam Rectal: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Diazepam Rectal
Dalfopristin
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of diazepam toxicity (excessive sedation, confusion)
Interaction Deep Dive
The concurrent administration of quinupristin/dalfopristin and diazepam may result in increased levels of diazepam. Quinupristin/dalfopristin is a major inhibitor of cytochrome P450 3A4 (CYP3A4) isoenzymes, and diazepam is a CYP3A4 substrate1.
Why it happens (mechanism)
Inhibition of cytochrome P450 3A4-mediated diazepam metabolism
Common questions
Can I take Dalfopristin and Diazepam Rectal together?
An increased risk of diazepam toxicity (excessive sedation, confusion) Always confirm with your pharmacist or prescriber before making any change.
How serious is the Dalfopristin and Diazepam Rectal interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "delayed". Effects tend to build up gradually over days to weeks.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Dalfopristin or Diazepam Rectal need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Product Information: Synercid(R) I.V. quinupristin and dalfopristin. Rhone-Poulenc Rorer Pharmaceuticals Inc. Collegeville, PA, 1999.
Keep reading about Diazepam Rectal
Keep reading about Dalfopristin
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