Diazepam Rectal

281 interactions 1,109 cited references
Also sold as: Diastat Diastat®
About Diazepam Rectal

Diazepam rectal gel is used in emergency situations to stop cluster seizures (episodes of increased seizure activity) in people who are taking other medications to treat epilepsy (seizures). Diazepam is in a class of medications called benzodiazepines. It works by calming abnormal overactivity in the brain. Read the full Diazepam Rectal drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Diazepam Rectal Abametapir Increased exposure of CYP3A4 substrate Details Diazepam Rectal Acepromazine PROMACE Increased risk of CNS depression Details Diazepam Rectal Alfentanil Increased risk of respiratory or CNS depression and hypotension Details Diazepam Rectal Alprazolam Xanax Increased risk of CNS depression Details Diazepam Rectal Amobarbital Amytal An increased risk of CNS and respiratory depression Details Diazepam Rectal Anileridine Increased risk of profound sedation, respiratory and CNS depression, coma and death Details Diazepam Rectal Apalutamide Erleada Reduced CYP2C19/CYP3A4 substrate exposure Details Diazepam Rectal Aprepitant Aponvie Increased exposure to benzodiazepines and an increased risk of benzodiazepine-related adverse reactions Details Diazepam Rectal Aripiprazole Abilify Increased risk of CNS depression and orthostatic hypotension Details Diazepam Rectal Aripiprazole Lauroxil Aristada Increased risk of CNS depression and orthostatic hypotension Details Diazepam Rectal Asenapine Saphris Increased risk of CNS depression Details Diazepam Rectal Avacopan Tavneos Increased CYP3A4 substrate exposure Details Diazepam Rectal Baclofen Fleqsuvy Increased risk of CNS depression Details Diazepam Rectal Benperidol Increased risk of CNS depression Details Diazepam Rectal Benzhydrocodone Increased risk of respiratory and CNS depression Details Diazepam Rectal Bromazepam Increased risk of respiratory or cardiovascular depression Details Diazepam Rectal Bromopride Potentiation of sedative effects Details Diazepam Rectal Buprenorphine Belbuca An increased risk of CNS depression and respiratory depression Details Diazepam Rectal Buspirone Bucapsol Increased risk of CNS depression Details Diazepam Rectal Butabarbital An increased risk of CNS and respiratory depression Details Diazepam Rectal Butalbital An increased risk of CNS depression Details Diazepam Rectal Butorphanol Butorphic Increased risk of respiratory and CNS depression Details Diazepam Rectal Calcifediol Rayaldee Altered serum levels of calcifediol Details Diazepam Rectal Calcium Oxybate Xywav An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Diazepam Rectal Cannabidiol Epidiolex Increased CYP2C19 substrate exposure, an increased risk of CYP2C19 substrate-related adverse reactions, an increased risk of CNS d... Details Diazepam Rectal Cannabis An increased risk of CNS depression Details Diazepam Rectal Carbamazepine Carbatrol Reduced diazePAM exposure, reduced diazePAM efficacy and an increased risk of respiratory depression, profound sedation, hypotensi... Details Diazepam Rectal Carbidopa Lodosyn An increased risk of CNS depression Details Diazepam Rectal Carbinoxamine Carbzah An increased risk of CNS depression Details Diazepam Rectal Carisoprodol Soma Additive respiratory depression Details Diazepam Rectal Carphenazine Increased risk of CNS depression Details Diazepam Rectal Cetirizine Aller-Tec Increased risk of CNS depression Details Diazepam Rectal Chloral Hydrate Additive respiratory depression Details Diazepam Rectal Chlordiazepoxide Increased risk of CNS depression Details Diazepam Rectal Chlorpromazine Increased risk of CNS depression Details Diazepam Rectal Chlorzoxazone Lorzone Additive respiratory depression Details Diazepam Rectal Clarithromycin Biaxin Increased exposure of CYP3A4 substrate and risk for toxicity Details

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