Danicopan and Methotrexate Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Methotrexate Injection
Danicopan
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased BCRP substrate exposure and an increased risk of BCRP substrate-related adverse effect
Interaction Deep Dive
Concomitant use of danicopan with BCRP substrates may increase the exposure of BCRP substrates, which may increase the risk of adverse reactions related to the BCRP substrate. In a drug interaction study, coadministration of a single oral dose of rosuvastatin 20 mg with danicopan dosed to steady state (200 mg three times a day for 4 days) resulted in increased rosuvastatin Cmax and AUC (0 to inf) by 3.3-fold and 2.2-fold, respectively. Monitor patients more frequently for adverse reactions associated with the BCRP substrate, and consider dose reduction of the BCRP substrate, if needed1.
Why it happens (mechanism)
Inhibition of BCRP-mediated efflux transport by danicopan
Literature reports
1 report — tap to read
a) In a drug interaction study, coadministration of a single oral dose of rosuvastatin 20 mg with danicopan dosed to steady state (200 mg three times a day for 4 days) resulted in increased rosuvastatin Cmax and AUC (0 to inf) by 3.3-fold and 2.2-fold, respectively 1.
Common questions
Can I take Danicopan and Methotrexate Injection together?
Increased BCRP substrate exposure and an increased risk of BCRP substrate-related adverse effect Always confirm with your pharmacist or prescriber before making any change.
How serious is the Danicopan and Methotrexate Injection interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Danicopan or Methotrexate Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: VOYDEYA(TM) oral tablets, danicopan oral tablets. Alexion Pharmaceuticals, Inc. (Per manufacturer), Boston, MA, 2024. DailyMed
Keep reading about Methotrexate Injection
Keep reading about Danicopan
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