Methotrexate Injection

354 interactions 996 cited references
Also sold as: Abitrexate® Folex® Jylamvo Mexate® Otrexup Otrexup® Rasuvo Rasuvo® Reditrex Reditrex® Trexall Xatmep
About Methotrexate Injection

Methotrexate injection is used alone or in combination with other medications: to treat certain types of acute lymphocytic leukemia (ALL) in adults and children; to treat or prevent meningeal leukemia (cancer in the covering of the spinal cord and brain) in adults and children; to treat certain types of non-Hodgkin's l… Read the full Methotrexate Injection drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Methotrexate Injection Abacavir Ziagen Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Acarbose Prandase® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Aceclofenac Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Acemetacin Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Acetazolamide Diamox® Sequels® Increased methotrexate exposure, an increased the risk of methotrexate-related severe AR, may also subsequently reduce active meta... Details Methotrexate Injection Acetohexamide Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Adalimumab Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Methotrexate Injection Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Methotrexate Injection Albendazole Albendamax Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Allopurinol Aloprim Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Alprazolam Xanax Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Ambrisentan Letairis Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Amiodarone Nexterone Increased methotrexate exposure, an increased risk of methotrexate toxicity or methotrexate-related severe adverse reactions, redu... Details Methotrexate Injection Amoxicillin Amoxi Drop Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Ampicillin Amcill® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Amtolmetin Guacil Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Anidulafungin Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Apalutamide Erleada Reduced OATP1B1/BCRP substrate exposure Details Methotrexate Injection Apixaban Eliquis Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Asciminib Scemblix Increased BCRP substrate exposure and an increased risk of BCRP substrate-related adverse effects Details Methotrexate Injection Asparaginase Decreased or elimination of methotrexate antineoplastic activity Details Methotrexate Injection Aspirin Acuprin® Increased methotrexate exposure, an increased risk of methotrexate toxicity, reduced active metabolite formation and possibly redu... Details Methotrexate Injection Atomoxetine Atoncy Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Atovaquone Mepron Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Azacitidine Onureg Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Azithromycin AzaSite Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Bacampicillin Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Balsalazide Colazal Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Balsalazide Disodium Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Beet Root Methotrexate toxicity Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.