Defactinib

16 interactions 1 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Letermovir Injection Lefamulin Lenacapavir Injection Lenacapavir Oral Nafcillin Injection Nizatidine
16 Major
All (16) Major (16)

Major

Defactinib Omeprazole Gastrobim Explained Reduced defactinib exposure and an reduced efficacy of defactinib Details Defactinib Dexlansoprazole Dexilant Reduced defactinib exposure and an reduced efficacy of defactinib Details Defactinib Encorafenib Braftovi Reduced defactinib exposure and reduced efficacy of defactinib Details Defactinib Esomeprazole Nexium Reduced defactinib exposure and an reduced efficacy of defactinib Details Defactinib Esomeprazole Injection Nexium Reduced defactinib exposure and an reduced efficacy of defactinib Details Defactinib Famotidine Calmicid Reduced defactinib exposure and an reduced efficacy of defactinib Details Defactinib Famotidine Injection Calmicid Reduced defactinib exposure and an reduced efficacy of defactinib Details Defactinib Ketoconazole Topical Extina® Foam Increased defactinib exposure and an increased risk of defactinib-related adverse effects Details Defactinib Lansoprazole Prevacid Reduced defactinib exposure and an reduced efficacy of defactinib Details Defactinib Lefamulin Xenleta Increased defactinib exposure and an increased risk of defactinib-related adverse effects Details Defactinib Lenacapavir Injection Sunlenca Increased defactinib exposure and an increased risk of defactinib-related adverse effects Details Defactinib Lenacapavir Oral Sunlenca Increased defactinib exposure and an increased risk of defactinib-related adverse effects Details Defactinib Letermovir Injection Prevymis Increased defactinib exposure and an increased risk of defactinib-related adverse effects Details Defactinib Mitapivat Aqvesme Reduced defactinib exposure and reduced efficacy of defactinib Details Defactinib Nafcillin Injection Unipen® Injection Reduced defactinib exposure and reduced efficacy of defactinib Details Defactinib Nizatidine Axid® Reduced defactinib exposure and an reduced efficacy of defactinib Details

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