Deferasirox and Tizanidine: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Tizanidine
No brand names on recordDeferasirox
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased tiZANidine exposure, an increased risk of tiZANidine-related hypotension, bradycardia or increased drowsiness
Interaction Deep Dive
Avoid use of deferasirox, a weak CYP1A2 inhibitor, with tiZANidine and other CYP1A2 substrates with a narrow therapeutic index. If coadministration is required, monitor for exposure-related toxicities1. Concomitant use of tiZANidine with deferasirox may increase tiZANidine exposure and may also increase risk of tiZANidine-related hypotension, bradycardia or increased drowsiness. If concomitant use is clinically necessary, reduce tiZANidine dosage or discontinue tiZANidine therapy 2.
Why it happens (mechanism)
Inhibition of CYP1A2-mediated metabolism of tiZANidine
Common questions
Can I take Deferasirox and Tizanidine together?
Increased tiZANidine exposure, an increased risk of tiZANidine-related hypotension, bradycardia or increased drowsiness Always confirm with your pharmacist or prescriber before making any change.
How serious is the Deferasirox and Tizanidine interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Deferasirox or Tizanidine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: JADENU(TM) oral tablets, deferasirox oral tablets. Novartis Pharmaceuticals (per manufacturer), East Hanover, NJ, 2015. DailyMed
- Product Information: ZANAFLEX(R) oral capsules, oral tablets, tizanidine HCl oral capsules, oral tablets. Legacy Pharma Inc. (per FDA), Georgetown, Grand Cayman, 2024. DailyMed
Keep reading about Tizanidine
Keep reading about Deferasirox
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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