Tizanidine
59 interactions 4 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
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Major
Tizanidine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of urinary retention and/or severe constipation leading to paralytic ileus, increased risk of profound sedation, re... Details Tizanidine Buprenorphine Belbuca Explained Enhanced neuromuscular blocking action, an increased risk of respiratory depression and CNS depression and an increased risk of pa... Details Tizanidine Abemaciclib Verzenio Explained Increased tiZANidine exposure and an increased risk of tiZANidine-related hypotension, bradycardia or increased drowsiness Details Tizanidine Acyclovir Avaclyr Increased tiZANidine exposure and an increased risk of tiZANidine-related hypotension, bradycardia or increased drowsiness Details Tizanidine Acyclovir Injection Avaclyr Increased tiZANidine exposure and an increased risk of tiZANidine-related hypotension, bradycardia or increased drowsiness Details Tizanidine Acyclovir Ophthalmic Avaclyr Increased tiZANidine exposure and an increased risk of tiZANidine-related hypotension, bradycardia or increased drowsiness Details Tizanidine Acyclovir Topical Zovirax Increased tiZANidine exposure and an increased risk of tiZANidine-related hypotension, bradycardia or increased drowsiness Details Tizanidine Allopurinol Aloprim Increased tiZANidine exposure and an increased risk of tiZANidine-related hypotension, bradycardia or increased drowsiness Details Tizanidine Allopurinol Injection Aloprim Increased tiZANidine exposure and an increased risk of tiZANidine-related hypotension, bradycardia or increased drowsiness Details Tizanidine Azathioprine Azasan An increased risk of hepatotoxicity Details Tizanidine Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Tizanidine Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Tizanidine Capmatinib Tabrecta Increased CYP1A2 substrate exposure and an increased risk of adverse reactions Details Tizanidine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Tizanidine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Tizanidine Deferasirox Exjade Increased tiZANidine exposure, an increased risk of tiZANidine-related hypotension, bradycardia or increased drowsiness Details Tizanidine Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Tizanidine Diazepam Rectal Diastat Increased risk of CNS depression Details Tizanidine Disulfiram Antabuse Increased tiZANidine exposure and an increased risk of tiZANidine-related hypotension, bradycardia or increased drowsiness Details Tizanidine Esketamine Nasal Spray Spravato Increased risk of sedation Details Tizanidine Estradiol Delestrogen Increased tiZANidine exposure and an increased risk of tiZANidine-related hypotension, bradycardia or increased drowsiness Details Tizanidine Estradiol Topical Divigel Increased tiZANidine exposure and an increased risk of tiZANidine-related hypotension, bradycardia or increased drowsiness Details Tizanidine Estradiol Transdermal Patch Alora® Increased tiZANidine exposure and an increased risk of tiZANidine-related hypotension, bradycardia or increased drowsiness Details Tizanidine Famotidine Calmicid Increased tiZANidine exposure, an increased risk of tiZANidine-related hypotension, bradycardia or increased drowsiness Details Tizanidine Famotidine Injection Calmicid Increased tiZANidine exposure, an increased risk of tiZANidine-related hypotension, bradycardia or increased drowsiness Details Tizanidine Fentanyl Transdermal Patch Duragesic® Increased risk of urinary retention and/or severe constipation leading to paralytic ileus and an increased risk of profound sedati... Details Tizanidine Glucagon Injection Baqsimi Increased risk of gastrointestinal side effects Details Tizanidine Glucagon Injection / Solution Baqsimi Increased risk of gastrointestinal side effects Details Tizanidine Glucagon Nasal Powder Baqsimi Increased risk of gastrointestinal side effects Details Tizanidine Glycopyrronium Topical Cuvposa® An increased risk of anticholinergic side effects Details Tizanidine Hydromorphone Injection Dilaudid Increased risk of urinary retention and/or severe constipation leading to paralytic ileus, increased risk of profound sedation, re... Details Tizanidine Hydromorphone Rectal available generically Increased risk of urinary retention and/or severe constipation leading to paralytic ileus, increased risk of profound sedation, re... Details Tizanidine Interferon Alfa-2B Injection Intron A® Increased tiZANidine exposure and an increased risk of tiZANidine-related hypotension, bradycardia or increased drowsiness Details Tizanidine Lacosamide Injection Motpoly An increased risk of CNS depression Details Tizanidine Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Tizanidine Levonorgestrel After banger Increased tiZANidine exposure and an increased risk of tiZANidine-related hypotension, bradycardia or increased drowsiness Details Tizanidine Levonorgestrel Intrauterine System Kyleena Increased tiZANidine exposure and an increased risk of tiZANidine-related hypotension, bradycardia or increased drowsiness Details Tizanidine Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Tizanidine Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... 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