Tizanidine

Name: Tizanidine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

59 interactions 4 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Enasidenib Cetirizine Ophthalmic Abemaciclib Acyclovir Estradiol Transdermal Patch Peginterferon Alfa-2A Injection

1 Contraindicated 51 Major 7 Moderate

All (59) Contraindicated (1) Major (51) Moderate (7)

Moderate

Tizanidine Lisinopril Prinivil Explained Potentiation of hypotensive response Details Tizanidine Aripiprazole Injection Abilify An increased risk of CNS depression and sedation Details Tizanidine Asenapine Transdermal Patch Secuado An increased risk of CNS depression and sedation Details Tizanidine Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details Tizanidine Diphenhydramine Injection Banophen An increased risk of CNS depression and sedation Details Tizanidine Diphenhydramine Topical Afterbite with Antihistamine An increased risk of CNS depression and sedation Details Tizanidine Obeticholic Acid Ocaliva Increased exposure to CYP1A2 substrate Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.