Deferasirox and Warfarin: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Warfarin
Deferasirox
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased warfarin exposure
Interaction Deep Dive
Concomitant administration of deferasirox, a CYP1A2 inhibitor, with a single dose of theophylline, a CYP1A2 substrate, resulted in an approximate doubling of the theophylline AUC and elimination half-life in healthy volunteers. Coadministration of warfarin, also a CYP1A2 inhibitor with a narrow therapeutic index, and deferasirox should be avoided as similar increases in plasma concentration may be expected, which may increase the risk of bleeding. If concomitant use is required, monitor patients closely1 for changes in prothrombin time/INR and symptoms of increased warfarin exposure.
Why it happens (mechanism)
Inhibition of CYP1A2-mediated warfarin metabolism by deferasirox
Common questions
Can I take Deferasirox and Warfarin together?
Increased warfarin exposure Always confirm with your pharmacist or prescriber before making any change.
How serious is the Deferasirox and Warfarin interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Deferasirox or Warfarin need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: EXJADE(R) oral suspension tablets, deferasirox oral suspension tablets. Novartis Pharmaceuticals Corporation (per FDA), East Hanover, NJ, 2012. DailyMed
- Product Information: COUMADIN(R) oral tablets, intravenous injection powder lyophilized for solution, warfarin sodium oral tablets, intravenous injection powder lyophilized for solution. Bristol-Myers Squibb Company (per FDA), Princeton, NJ, 2011. DailyMed
Keep reading about Warfarin
Keep reading about Deferasirox
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
Check another combination
Our instant two-drug interaction checker is almost here.
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacist