Drug Interaction Report

Delavirdine and Dexamethasone Ophthalmic: Interaction Details

Name: Delavirdine and Dexamethasone Ophthalmic Interaction
Creator: Dr. Brian Staiger, PharmD, BCPS

A pharmacist-reviewed analysis of the Delavirdine and Dexamethasone Ophthalmic interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Delavirdine

Rescriptor®

Dexamethasone Ophthalmic

Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Dexair Dexasporin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Maxidex® Maxitrol® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Neodecadron® (as a combination product containing Dexamethasone, Neomycin) TobraDex® (as a combination product containing Dexamethasone, Tobramycin)

Medically reviewed by

Dr. Brian Staiger, PharmD, BCPS

Updated Aug 8, 2026

Editorial policy · Data sources

Interaction severity

Moderate

Can be significant — usually manageable with monitoring.

Minor

Moderate

Major

Contraindicated

How we grade severity & evidence

Severity levels

Contraindicated: These should generally not be used together.
Major: Potentially serious — often needs a change or close monitoring.
Moderate: Can be significant — usually manageable with monitoring.
Minor: Usually limited clinical impact.

Evidence grades

Established: Well documented — supported by controlled studies or strong clinical data.
Probable: Good supporting evidence, though not definitively proven.
Suspected: Some evidence suggests this interaction, but it is not well established.
Possible: Limited or conflicting evidence; the interaction may occur.
Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 50 documented Delavirdine interactions, 13 are rated moderate — including this one.

Onset

delayed

Evidence

theoretical

Severity

Moderate

What happens

Reduced delavirdine effectiveness

Interaction Deep Dive

Coadministration of dexamethasone and delavirdine may result in reduced delavirdine serum concentrations. The mechanism of action is thought to be induction by dexamethasone of CYP450-mediated delavirdine metabolism, thereby reducing delavirdine levels and clinical efficacy. Use caution when these agents are coadministered¹. Monitor patients closely for clinical response to delavirdine and make upward dose adjustments, if necessary.

Why it happens (mechanism)

Induction of CYPP450-mediated delavirdine metabolism

Common questions

Can I take Delavirdine and Dexamethasone Ophthalmic together?

Reduced delavirdine effectiveness Always confirm with your pharmacist or prescriber before making any change.

How serious is the Delavirdine and Dexamethasone Ophthalmic interaction?

It is rated moderate. Can be significant — usually manageable with monitoring.

How quickly could this interaction happen?

The documented onset is "delayed". Effects tend to build up gradually over days to weeks.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

Does my dose of Delavirdine or Dexamethasone Ophthalmic need adjusting while I take them together?
What symptoms should prompt me to call you or my prescriber right away?
Does the timing of my doses matter for this combination?
Is there anything you'd monitor while I'm on both?

References (1)

Product Information: RESCRIPTOR(R) oral tablets, delavirdine mesylate oral tablets. Pfizer,Inc, New York, NY, 2006.

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Delavirdine

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Dexamethasone Ophthalmic

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All Dexamethasone Ophthalmic interactions (308) Dexamethasone Ophthalmic drug information

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HelloPharmacist doesn't license one of the big commercial interaction databases, so what you'll find here is not a complete list of every known drug interaction. Instead, each entry is researched, analyzed, and written up individually — documented from the published literature, reviewed by a pharmacist, and cited so you can check every source yourself.

If a combination isn't listed here, it means we haven't documented it yet — never that it's safe. For screening a full medication list, we recommend pairing this site with a comprehensive tool like the Drugs.com Interaction Checker and, most importantly, a review by your own pharmacist. For a deep, plain-English, fully sourced explanation of a specific documented interaction — that's exactly what we built this for.

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