Desvenlafaxine

68 interactions 5 explained in plain English
Also sold as: Pristiq
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Metoclopramide Injection Metoclopramide Nasal Spray Linezolid Injection Palonosetron Injection Clopidogrel Flurbiprofen Ophthalmic
3 Contraindicated 64 Major 1 Moderate
All (68) Contraindicated (3) Major (64) Moderate (1)

Major

Desvenlafaxine Fondaparinux Injection Arixtra An increased risk of bleeding Details Desvenlafaxine Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Desvenlafaxine Granisetron Injection Granisol Increased risk of serotonin syndrome Details Desvenlafaxine Heparin An increased risk of bleeding Details Desvenlafaxine Heparin Injection Lipo-Hepin® An increased risk of bleeding Details Desvenlafaxine Hydromorphone Injection Dilaudid Increased risk of serotonin syndrome Details Desvenlafaxine Hydromorphone Rectal available generically Increased risk of serotonin syndrome Details Desvenlafaxine Hydroxychloroquine Plaquenil An increased risk of seizures Details Desvenlafaxine Ibuprofen Addaprin An increased risk of bleeding Details Desvenlafaxine Iloprost Aurlumyn An increased risk of bleeding Details Desvenlafaxine Ketoprofen Actron® An increased risk of bleeding Details Desvenlafaxine Ketorolac Acular An increased risk of bleeding Details Desvenlafaxine Ketorolac Injection Acular An increased risk of bleeding Details Desvenlafaxine Ketorolac Nasal Spray Sprix An increased risk of bleeding Details Desvenlafaxine Ketorolac Ophthalmic Acular An increased risk of bleeding Details Desvenlafaxine Lithium Carbonate Lithobid Increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Desvenlafaxine Meclofenamate Meclodium® An increased risk of bleeding Details Desvenlafaxine Mefenamic Acid Ponstel® An increased risk of bleeding Details Desvenlafaxine Meloxicam Alloxate An increased risk of bleeding Details Desvenlafaxine Meloxicam Injection Alloxate An increased risk of bleeding Details Desvenlafaxine Mexiletine Mexitil® Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse events Details Desvenlafaxine Morphine Injection Astramorph® PF Increased risk of serotonin syndrome Details Desvenlafaxine Nabumetone Relafen An increased risk of bleeding Details Desvenlafaxine Nalbuphine Injection Nubain® Increased risk of serotonin syndrome Details Desvenlafaxine Naproxen Aleve An increased risk of bleeding Details Desvenlafaxine Nebivolol Bystolic Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse events Details Desvenlafaxine Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

Moderate

Desvenlafaxine Lumateperone Caplyta An increased risk for serotonin reuptake inhibitor (SRI)-associated adverse reactions Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.