Desvenlafaxine
68 interactions 5 explained in plain English
Also sold as:
Pristiq
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Metoclopramide Injection
Metoclopramide Nasal Spray
Linezolid Injection
Palonosetron Injection
Clopidogrel
Flurbiprofen Ophthalmic
Contraindicated
Desvenlafaxine Linezolid Injection Zyvox Increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Desvenlafaxine Metoclopramide Injection Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Desvenlafaxine Metoclopramide Nasal Spray Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome DetailsMajor
Desvenlafaxine Acetaminophen And Codeine Capital® & Codeine Explained Increased CYP2D6 substrate exposure and an increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonu... Details Desvenlafaxine Amitriptyline Elavil Explained Increased CYP2D6 substrate exposure and an increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonu... Details Desvenlafaxine Sertraline Explained Increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Desvenlafaxine Buprenorphine Belbuca Explained An increased risk of serotonin syndrome Details Desvenlafaxine Apixaban Eliquis Explained An increased risk of bleeding and can cause serious, potentially fatal bleeding Details Desvenlafaxine Aripiprazole Injection Abilify Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse events Details Desvenlafaxine Aspirin Acuprin® An increased risk of bleeding Details Desvenlafaxine Aspirin Rectal Aspirin An increased risk of bleeding Details Desvenlafaxine Betrixaban Bevyxxa® An increased risk of bleeding Details Desvenlafaxine Anagrelide Agrylin An increased risk of bleeding Details Desvenlafaxine Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Desvenlafaxine Butorphanol Injection Butorphic Increased risk of serotonin syndrome Details Desvenlafaxine Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome Details Desvenlafaxine Clopidogrel Plavix An increased risk of bleeding Details Desvenlafaxine Dabigatran Pradaxa® An increased risk of bleeding Details Desvenlafaxine Dabigatran Etexilate An increased risk of bleeding Details Desvenlafaxine Dalteparin Injection Fragmin An increased risk of bleeding Details Desvenlafaxine Deutetrabenazine Austedo Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse events Details Desvenlafaxine Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Desvenlafaxine Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Desvenlafaxine Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Desvenlafaxine Diclofenac Transdermal Patch Flector An increased risk of bleeding Details Desvenlafaxine Dipyridamole Permole® An increased risk of bleeding Details Desvenlafaxine Dolasetron Anzemet Increased risk of serotonin syndrome Details Desvenlafaxine Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Desvenlafaxine Doxorubicin Adriamycin Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse events Details Desvenlafaxine Edoxaban Savaysa Increased risk of bleeding Details Desvenlafaxine Enoxaparin Lovenox An increased risk of bleeding Details Desvenlafaxine Enoxaparin Injection Lovenox An increased risk of bleeding Details Desvenlafaxine Epoprostenol Flolan An increased risk of bleeding Details Desvenlafaxine Etodolac Lodine An increased risk of bleeding Details Desvenlafaxine Fenoprofen Fenopron An increased risk of bleeding Details Desvenlafaxine Fentanyl Transdermal Patch Duragesic® Increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Desvenlafaxine Flecainide Tambocor® Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse events Details Desvenlafaxine Flurbiprofen Ansaid An increased risk of bleeding Details Desvenlafaxine Flurbiprofen Ophthalmic Ocufen An increased risk of bleeding Details Desvenlafaxine Fondaparinux Arixtra An increased risk of bleeding DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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