Drug Interaction Report

Dexamethasone Ophthalmic and Lazertinib: Interaction Details

A pharmacist-reviewed analysis of the Dexamethasone Ophthalmic and Lazertinib interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Dexamethasone Ophthalmic

Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Dexair Dexasporin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Maxidex® Maxitrol® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Neodecadron® (as a combination product containing Dexamethasone, Neomycin) TobraDex® (as a combination product containing Dexamethasone, Tobramycin)
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Lazertinib

Lazcluze
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 308 documented Dexamethasone Ophthalmic interactions, 220 are rated major — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
unspecified
Evidence
theoretical
Severity
Major

What happens

Reduced lazertinib exposure and reduced efficacy of lazertinib

Interaction Deep Dive

Avoid coadministration of lazertinib with a strong or moderate CYP3A4 inducer as it may reduce lazertinib exposure. Concomitant use of rifAMPin (strong CYP3A4 inducer) with lazertinib decreased lazertinib Cmax by 72% and AUC by 83%. And, concomitant use of efavirenz (moderate CYP3A4 inducer) with lazertinib is predicted to decrease lazertinib steady state Cmax by at least 32% and AUC by at least 44%. Consider an alternative concomitant medication with no potential to induce CYP3A41.

Why it happens (mechanism)

Induction of CYP3A4-mediated metabolism of lazertinib

Literature reports

2 reports — tap to read

a) Concomitant use of rifAMPin (strong CYP3A4 inducer) with lazertinib decreased lazertinib Cmax by 72% and AUC by 83% 1.

b) Concomitant use of efavirenz (moderate CYP3A4 inducer) with lazertinib is predicted to decrease lazertinib steady state Cmax by at least 32% and AUC by at least 44% 1.

Common questions

Can I take Dexamethasone Ophthalmic and Lazertinib together?

Reduced lazertinib exposure and reduced efficacy of lazertinib Always confirm with your pharmacist or prescriber before making any change.

How serious is the Dexamethasone Ophthalmic and Lazertinib interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

  • Does my dose of Dexamethasone Ophthalmic or Lazertinib need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (1)

  1. Product Information: LAZCLUZE™ oral tablets, lazertinib oral tablets. Janssen Biotech, Inc. (Per FDA), Horsham, PA, 2025. DailyMed
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Dexamethasone Ophthalmic

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Lazertinib

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