Dexamethasone

74 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Desmopressin Nasal Flurbiprofen Ophthalmic Meclofenamate Buprenorphine Gatifloxacin Ophthalmic Ofloxacin Otic
1 Contraindicated 61 Major 11 Moderate 1 Minor
All (74) Contraindicated (1) Major (61) Moderate (11) Minor (1)

Major

Dexamethasone Levofloxacin Injection Levaquin An increased risk of tendon rupture Details Dexamethasone Levonorgestrel After banger Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Dexamethasone Levonorgestrel Intrauterine System Kyleena Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Dexamethasone Lumateperone Caplyta Reduced lumateperone exposure Details Dexamethasone Meclofenamate Meclodium® Increased risk of gastrointestinal ulcer or bleeding Details Dexamethasone Medroxyprogesterone Amen® Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Dexamethasone Medroxyprogesterone Injection Depo-Provera Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Dexamethasone Mefenamic Acid Ponstel® Increased risk of gastrointestinal ulcer or bleeding Details Dexamethasone Meloxicam Alloxate Increased risk of gastrointestinal ulcer or bleeding Details Dexamethasone Meloxicam Injection Alloxate Increased risk of gastrointestinal ulcer or bleeding Details Dexamethasone Moxifloxacin Avelox An increased risk of tendon rupture Details Dexamethasone Moxifloxacin Injection Avelox An increased risk of tendon rupture Details Dexamethasone Moxifloxacin Ophthalmic Moxeza® An increased risk of tendon rupture Details Dexamethasone Nabumetone Relafen Increased risk of gastrointestinal ulcer or bleeding Details Dexamethasone Naproxen Aleve Increased risk of gastrointestinal ulcer or bleeding Details Dexamethasone Nevirapine Viramune Decreased nevirapine plasma concentrations Details Dexamethasone Nifedipine Adalat® Reduced NIFEdipine exposure Details Dexamethasone Nimodipine Nimotop Reduced nimodipine plasma concentrations and reduced nimodipine efficacy Details Dexamethasone Ofloxacin Floxin® An increased risk of tendon rupture Details Dexamethasone Ofloxacin Ophthalmic Ocuflox An increased risk of tendon rupture Details Dexamethasone Ofloxacin Otic Floxin® Otic An increased risk of tendon rupture Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.