Dexamethasone

74 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Dexamethasone Acetaminophen And Codeine Capital® & Codeine Explained Reduced codeine and morphine exposure, reduced opioid efficacy and precipitation of opioid withdrawal Details Dexamethasone Abametapir Explained Increased exposure of CYP3A4 substrate Details Dexamethasone Buprenorphine Belbuca Explained Reduced buprenorphine exposure and reduced efficacy of buprenorphine Details Dexamethasone Aldesleukin Proleukin Reduced antitumor effectiveness Details Dexamethasone Aspirin Acuprin® An increased risk of salicylism subsequent to withdrawal of corticosteroids Details Dexamethasone Aspirin Rectal Aspirin An increased risk of salicylism subsequent to withdrawal of corticosteroids Details Dexamethasone Atogepant Qulipta Reduced atogepant exposure Details Dexamethasone Cariprazine Vraylar Explained Effects on the cariprazine exposure has not been evaluated and the net effect is unclear Details Dexamethasone Amlodipine Amvaz® Reduced amLODIPine exposure Details Dexamethasone Besifloxacin Ophthalmic Besivance An increased risk of tendon rupture Details Dexamethasone Bromfenac Ophthalmic Bromday® Increased risk of gastrointestinal ulcer or bleeding Details Dexamethasone Cholestyramine Resin Locholest® Decreased dexamethasone concentration Details Dexamethasone Cyclosporine Injection Atopica Reduced cycloSPORINE exposure Details Dexamethasone Cyclosporine Ophthalmic Cequa Reduced cycloSPORINE exposure Details Dexamethasone Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of gastrointestinal ulcer or bleeding Details Dexamethasone Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of gastrointestinal ulcer or bleeding Details Dexamethasone Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of gastrointestinal ulcer or bleeding Details Dexamethasone Diclofenac Transdermal Patch Flector Increased risk of gastrointestinal ulcer or bleeding Details Dexamethasone Doxorubicin Adriamycin Reduced DOXOrubicin exposure Details Dexamethasone Estradiol Delestrogen Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Dexamethasone Estradiol Topical Divigel Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Dexamethasone Estradiol Transdermal Patch Alora® Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Dexamethasone Etodolac Lodine Increased risk of gastrointestinal ulcer or bleeding Details Dexamethasone Fenoprofen Fenopron Increased risk of gastrointestinal ulcer or bleeding Details Dexamethasone Fentanyl Transdermal Patch Duragesic® Reduced exposure of fentaNYL, reduced efficacy of fentaNYL and/or onset of opioid withdrawal symptoms Details Dexamethasone Flurbiprofen Ansaid Increased risk of gastrointestinal ulcer or bleeding Details Dexamethasone Flurbiprofen Ophthalmic Ocufen Increased risk of gastrointestinal ulcer or bleeding Details Dexamethasone Gatifloxacin Ophthalmic Zymar® An increased risk of tendon rupture Details Dexamethasone Gemifloxacin Factive An increased risk of tendon rupture Details Dexamethasone Ibuprofen Addaprin Increased risk of gastrointestinal ulcer or bleeding Details Dexamethasone Ketoconazole Topical Extina® Foam Increased dexAMETHasone exposure Details Dexamethasone Ketoprofen Actron® Increased risk of gastrointestinal ulcer or bleeding Details Dexamethasone Ketorolac Acular Increased risk of gastrointestinal ulcer or bleeding Details Dexamethasone Ketorolac Injection Acular Increased risk of gastrointestinal ulcer or bleeding Details Dexamethasone Ketorolac Nasal Spray Sprix Increased risk of gastrointestinal ulcer or bleeding Details Dexamethasone Ketorolac Ophthalmic Acular Increased risk of gastrointestinal ulcer or bleeding Details Dexamethasone Lenacapavir Injection Sunlenca Increased dexAMETHasone exposure, an increased risk of Cushing's syndrome and adrenal suppression, reduced lenacapavir exposure an... Details Dexamethasone Lenacapavir Oral Sunlenca Increased dexAMETHasone exposure, an increased risk of Cushing's syndrome and adrenal suppression, reduced lenacapavir exposure an... Details Dexamethasone Letermovir Injection Prevymis Increased CYP3A substrate exposure Details

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