Dexibuprofen
87 interactions 5 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
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Pemetrexed Injection
Major
Dexibuprofen Hydrocortisone Ala-Cort Increased risk of gastrointestinal ulcer or bleeding Details Dexibuprofen Hydrocortisone Injection A-Hydrocort® Increased risk of gastrointestinal ulcer or bleeding Details Dexibuprofen Ibuprofen Addaprin Increased risk of bleeding Details Dexibuprofen Iloprost Aurlumyn An increased risk of bleeding Details Dexibuprofen Ketoprofen Actron® Increased risk of bleeding Details Dexibuprofen Lithium Carbonate Lithobid Increased lithium exposure and an increased risk of lithium toxicity Details Dexibuprofen Meclofenamate Meclodium® Increased risk of bleeding Details Dexibuprofen Mefenamic Acid Ponstel® Increased risk of bleeding Details Dexibuprofen Meloxicam Alloxate Increased risk of bleeding Details Dexibuprofen Meloxicam Injection Alloxate Increased risk of bleeding Details Dexibuprofen Melphalan Alkeran An increased risk of bleeding Details Dexibuprofen Melphalan Injection Alkeran An increased risk of bleeding Details Dexibuprofen Mesalamine Apriso Increased risk of bleeding Details Dexibuprofen Mesalamine Rectal Canasa Increased risk of bleeding Details Dexibuprofen Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Dexibuprofen Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Dexibuprofen Nabumetone Relafen Increased risk of bleeding Details Dexibuprofen Naproxen Aleve Increased risk of bleeding Details Dexibuprofen Pemetrexed Injection Alimta Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... DetailsModerate
Dexibuprofen Lisinopril Prinivil Explained Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Dexibuprofen Atenolol Tenormin Explained Reduced antihypertensive effect Details Dexibuprofen Acebutolol Sectral® Reduced antihypertensive effect Details Dexibuprofen Benazepril Lotensin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Dexibuprofen Azilsartan Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Dexibuprofen Betaxolol Betoptic S Reduced antihypertensive effect Details Dexibuprofen Betaxolol Ophthalmic Betoptic® Reduced antihypertensive effect Details Dexibuprofen Bisoprolol Zebeta® Reduced antihypertensive effect Details Dexibuprofen Captopril Capoten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Dexibuprofen Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Dexibuprofen Enalapril Epaned Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Dexibuprofen Eprosartan Teveten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Dexibuprofen Esmolol Brevibloc Reduced antihypertensive effect Details Dexibuprofen Fosinopril Monopril® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Dexibuprofen Irbesartan Avapro Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Dexibuprofen Labetalol Normodyne® Reduced antihypertensive effect Details Dexibuprofen Levobunolol Ophthalmic AKBeta® Reduced antihypertensive effect Details Dexibuprofen Levofloxacin Levaquin An increased risk of seizures Details Dexibuprofen Levofloxacin Injection Levaquin An increased risk of seizures Details Dexibuprofen Losartan Arbli Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Dexibuprofen Moexipril Univasc® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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