Dexibuprofen

87 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ophthalmic Ketorolac Ketorolac Nasal Spray Ketorolac Injection Furosemide Injection Pemetrexed Injection
4 Contraindicated 55 Major 28 Moderate
All (87) Contraindicated (4) Major (55) Moderate (28)

Major

Dexibuprofen Ketoprofen Actron® Increased risk of bleeding Details Dexibuprofen Lithium Carbonate Lithobid Increased lithium exposure and an increased risk of lithium toxicity Details Dexibuprofen Meclofenamate Meclodium® Increased risk of bleeding Details Dexibuprofen Mefenamic Acid Ponstel® Increased risk of bleeding Details Dexibuprofen Meloxicam Alloxate Increased risk of bleeding Details Dexibuprofen Meloxicam Injection Alloxate Increased risk of bleeding Details Dexibuprofen Melphalan Alkeran An increased risk of bleeding Details Dexibuprofen Melphalan Injection Alkeran An increased risk of bleeding Details Dexibuprofen Mesalamine Apriso Increased risk of bleeding Details Dexibuprofen Mesalamine Rectal Canasa Increased risk of bleeding Details Dexibuprofen Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Dexibuprofen Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Dexibuprofen Nabumetone Relafen Increased risk of bleeding Details Dexibuprofen Naproxen Aleve Increased risk of bleeding Details Dexibuprofen Pemetrexed Injection Alimta Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.