Dexlansoprazole and Risedronate: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Risedronate
Dexlansoprazole
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased risedronate bioavailability
Interaction Deep Dive
Concomitant administration of enteric-coated risedronate sodium (Atelvia(TM)) delayed-release tablets and a proton pump inhibitor, such as dexlansoprazole1, may increase the bioavailability of risedronate. In drug interaction studies between risedronate delayed-release tablets and esomeprazole, also a proton pump inhibitor, the Cmax and AUC of risedronate increased 60% and 22%, respectively. Due the possible increase in risedronate bioavailability, the concomitant use of dexlansoprazole and enteric-coated risedronate sodium (Atelvia(TM)) delayed-release tablets is not recommended 2.
Why it happens (mechanism)
Increased stomach pH resulting in faster release of enteric-coated products
Literature reports
1 report — tap to read
a) During a phase 1, 2-period, crossover study of 60 healthy postmenopausal women coadministration of esomeprazole, a proton pump inhibitor like dexlansoprazole, and delayed-release risedronate tablet resulted in increased risedronate AUC and Cmax. The women were administered a single dose of delayed-release risedronate 35 mg after breakfast following 6 days of treatment with delayed-release esomeprazole 40 mg. On day 6, esomeprazole 40 mg was administered one hour prior to breakfast with 240 mL of water. Risedronate delayed-release 35 mg was administered within 10 minutes of breakfast with an additional 240 mL of water. Laboratory tests revealed an increase of 60% and 22% in risedronate Cmax and AUC, respectively, in the presence of esomeprazole 2.
Common questions
Can I take Dexlansoprazole and Risedronate together?
Increased risedronate bioavailability Always confirm with your pharmacist or prescriber before making any change.
How serious is the Dexlansoprazole and Risedronate interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Dexlansoprazole or Risedronate need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (2)
- Product Information: DEXILANT(TM) oral delayed-release capsules, dexlansoprazole oral delayed-release capsules. Takeda Pharmaceuticals America, Inc. (per FDA), Deerfield, IL, 2012. DailyMed
- Product Information: Atelvia(R) oral delayed release tablets, risedronate sodium oral delayed release tablets. Warner Chilcott (US), LLC (per FDA), Rockaway, NJ, 2012. DailyMed
Keep reading about Risedronate
Keep reading about Dexlansoprazole
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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