Dexmethylphenidate

Name: Dexmethylphenidate Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

6 interactions

Also sold as: Focalin Focalin® Focalin® XR

About Dexmethylphenidate

Dexmethylphenidate is a central nervous system stimulant used to help control attention and behavior problems in ADHD. Read the full Dexmethylphenidate drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Linezolid Injection Azathioprine Mercaptopurine Methotrexate Methotrexate Injection Olodaterol Oral Inhalation

1 Contraindicated 5 Major

All (6) Contraindicated (1) Major (5)

Major

Dexmethylphenidate Azathioprine Azasan An increased risk of hepatotoxicity Details Dexmethylphenidate Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Dexmethylphenidate Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Dexmethylphenidate Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Dexmethylphenidate Olodaterol Oral Inhalation Striverdi An increased risk of clinically significant cardiovascular effects and fatalities and an increased/potentiated sympathetic effects... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.