Dextroamphetamine

56 interactions 7 explained in plain English
Also sold as: Dexedrine ProCentra Zenzedi
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Linezolid Injection Clonidine Transdermal Patch Dexlansoprazole Amitriptyline Estradiol Dacomitinib
1 Contraindicated 53 Major 2 Moderate
All (56) Contraindicated (1) Major (53) Moderate (2)

Major

Dextroamphetamine Lansoprazole Prevacid Increased exposure to amphetamine Details Dextroamphetamine Levonorgestrel After banger Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Dextroamphetamine Levonorgestrel Intrauterine System Kyleena Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Dextroamphetamine Lithium Carbonate Lithobid An increased risk of serotonin syndrome Details Dextroamphetamine Medroxyprogesterone Amen® Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Dextroamphetamine Medroxyprogesterone Injection Depo-Provera Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Dextroamphetamine Methylphenidate Adhansia XR® Increased d-amphetamine in the brain and an increased risk of potentiated cardiovascular events Details Dextroamphetamine Methylphenidate Transdermal Patch Daytrana Increased d-amphetamine in the brain and an increased risk of potentiated cardiovascular events Details Dextroamphetamine Morphine Injection Astramorph® PF Increased risk of serotonin syndrome Details Dextroamphetamine Nalbuphine Injection Nubain® An increased risk of serotonin syndrome Details Dextroamphetamine Nicardipine Cardene Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Dextroamphetamine Olodaterol Oral Inhalation Striverdi An increased risk of clinically significant cardiovascular effects and fatalities and an increased/potentiated sympathetic effects... Details Dextroamphetamine Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.