Diazoxide and Acetaminophen And Codeine: Interaction Details
AI-assisted, pharmacist-reviewed · AI content regenerated Jul 11, 2026 · Source data updated Jun 30, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Acetaminophen And Codeine
Diazoxide
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
You've been prescribed Tylenol with codeine along with diazoxide (Proglycem). Here's the idea behind this interaction. Codeine, an opioid, can nudge your body to release a hormone that makes you hold onto more water. Diazoxide can act like a water pill, and the extra water your body keeps may make it work a little less well. This could show up as less fluid coming off or changes in your blood pressure.
I want to reassure you that this is a theoretical concern, not something proven to happen often. Please keep taking both exactly as prescribed. Your care team can easily watch for this and adjust your dose if needed. Just let them know how you're feeling.
Effect: Codeine may reduce diazoxide's diuretic/antihypertensive efficacy.
Mechanism: Opioid-mediated increase in antidiuretic hormone (ADH) release promotes water retention, opposing diuresis. Note: codeine is a prodrug activated via CYP2D6, but this interaction is pharmacodynamic (opposing effect on fluid balance), not PK-based.
Direction: Reduced diuretic effect. Onset: unspecified. Evidence: theoretical. Severity: major on file.
- Monitor for diminished diuresis, edema, and blood pressure changes.
- Diazoxide dose may need individualization by the care team.
- Reassess if opioid therapy is prolonged.
What happens
Reduced diuretic efficacy
Interaction Deep Dive
Concomitant use of codeine with diuretics may reduce the efficacy of diuretics by inducing the release of anti-diuretic hormone. Monitor patients for signs of diminished diuresis and/or effects on blood pressure and increase the dosage of the diuretic as needed1.
Why it happens (mechanism)
Increased opioid-mediated release of antidiuretic hormone
How to manage this interaction
Keep taking both medicines as prescribed unless your prescriber tells you otherwise. This is a theoretical interaction, and your care team can manage it.
- Your team may monitor you more closely for signs the diazoxide is working less well, such as swelling, less urine output, or blood pressure changes.
- The diazoxide dose may need to be adjusted and individualized by your care team if they see reduced effect.
- Tell your pharmacist or doctor if you notice new swelling, weight gain, or blood pressure changes while on the codeine.
Management is individual — confirm any change with your pharmacist or prescriber.
Common questions
Can I take Diazoxide and Acetaminophen And Codeine together?
Codeine may slightly weaken diazoxide's effect by causing your body to hold water, but this is theoretical; keep taking both and let your care team monitor and adjust the dose if needed. Always confirm with your pharmacist or prescriber before making any change.
How serious is the Diazoxide and Acetaminophen And Codeine interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How is the Diazoxide and Acetaminophen And Codeine interaction managed?
Keep taking both medicines as prescribed unless your prescriber tells you otherwise. This is a theoretical interaction, and your care team can manage it. Your team may monitor you more closely for signs the diazoxide is working less well, such as swelling, less urine output, or blood pressure changes. The diazoxide dose may need to be adjusted and individualized by your care team if they see reduc… Management is individual — always follow your own care team's guidance.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Diazoxide or Acetaminophen And Codeine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: CARISOPRODOL, ASPIRIN, CODEINE PHOSPHATE oral tablets, carisoprodol, aspirin, codeine phosphate oral tablets. Ingenus Pharmaceuticals LLC (per DailyMed), Orlando, FL, 2021. DailyMed
Keep reading about Acetaminophen And Codeine
Keep reading about Diazoxide
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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