Dibekacin and Furosemide Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Furosemide Injection
Dibekacin
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Ototoxicity and/or nephrotoxicity
Interaction Deep Dive
There is evidence that concurrently administered furosemide and aminoglycosides may increase the risk of nephrotoxicity and ototoxicity23456. Avoid excessive doses of either drug, especially in uremic patients, as there is evidence to suggest that renal dysfunction will increase the risk of ototoxicity 17.
Why it happens (mechanism)
Additive or synergistic toxicity
Literature reports
1 report — tap to read
a) The effects of furosemide-aminoglycoside combination therapy on ototoxicity was studied. As measured by audiograms, toxicity developed in 5 out of 23 patients (21.7%) receiving furosemide and aminoglycosides and in 28 out of 119 patients (23.5%) who received only an aminoglycoside. However, only a small number of patients received combination therapy, as opposed to single agent furosemide therapy. Significant differences may have been detected with larger numbers of patients receiving the combination. The same authors also conducted a retrospective study of the influence of furosemide on aminoglycoside-induced nephrotoxicity. Nephrotoxicity was defined as a rise in serum creatinine of greater than or equal to 0.5 mg/dL if the original concentration was less than 3 mg/dL or a rise of greater than or equal to 1 mg/dL if the original concentration was 3 mL/dL or greater. Results demonstrated nephrotoxicity in 10 out of 50 patients (20%) given furosemide and aminoglycoside and in 38 out of 222 patients (17.1%) given only an aminoglycoside. The authors concluded that the coadministration of furosemide with aminoglycosides should not be considered a major risk factor for the development of aminoglycoside-induced nephrotoxicity or auditory toxicity 2.
Common questions
Can I take Dibekacin and Furosemide Injection together?
Ototoxicity and/or nephrotoxicity Always confirm with your pharmacist or prescriber before making any change.
How serious is the Dibekacin and Furosemide Injection interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "rapid". Effects can appear quickly, often within about 24 hours of combining the drugs.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Dibekacin or Furosemide Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (7)
- Kaka JS, Lyman C, & Kilarski DJ: Tobramycin-furosemide interaction. Drug Intell Clin Pharm 1984; 18:235-238. PubMed
- Smith CR & Lietman PS: Effect of furosemide on aminoglycoside-induced nephrotoxicity and auditory toxicity in humans. Antimicrob Agents Chemother 1983; 23:133-137. DOI
- Whiting PH, Barber HE, & Petersen J: The effect of frusemide and piretanide on the renal clearance of gentamicin in man. Br J Clin Pharmacol 1981; 12:795-799. DOI
- Brummett RE, Bendrick T, & Himes D: Comparative ototoxicity of bumetanide and furosemide when used in combination with kanamycin. J Clin Pharmacol 1981; 21:628-636. DOI
- Quick CA & Hoppe W: Permanent deafness associated with furosemide administration. Ann Otol Rhinol Laryngol 1975; 84:94-101. PubMed
- Rybak LP: Furosemide ototoxicity: clinical and experimental aspects. Laryngoscope 1985; 95(9 part 2 suppl 38):1-14. DOI
- Quick CA: Hearing loss in patients with dialysis and renal transplants. Ann Otol Rhinol Laryngol 1976; 85:776-790. PubMed
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