Diclofenac Ophthalmic

268 interactions 703 cited references
Also sold as: Voltaren® Eye Drops
About Diclofenac Ophthalmic

Diclofenac ophthalmic solution is used to treat eye pain, redness, and swelling in patients who are recovering from cataract surgery (procedure to treat clouding of the lens in the eye). Diclofenac ophthalmic solution is also used to temporarily relieve eye pain and sensitivity to light in patients who are recovering f… Read the full Diclofenac Ophthalmic drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Moderate

Diclofenac Ophthalmic Metoprolol Kapspargo Reduced antihypertensive effect Details Diclofenac Ophthalmic Miconazole Aloe Vesta Antifungal Increased exposure of diclofenac Details Diclofenac Ophthalmic Mifepristone Korlym Increased NSAID exposure Details Diclofenac Ophthalmic Moexipril Univasc® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Ophthalmic Nadolol Corgard Reduced antihypertensive effect Details Diclofenac Ophthalmic Nebivolol Bystolic Reduced antihypertensive effect Details Diclofenac Ophthalmic Norfloxacin An increased risk of seizures Details Diclofenac Ophthalmic Ofloxacin Floxin® An increased risk of seizures Details Diclofenac Ophthalmic Olmesartan Benicar Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Ophthalmic Oxprenolol Reduced antihypertensive effect Details Diclofenac Ophthalmic Penbutolol Levatol® Reduced antihypertensive effect Details Diclofenac Ophthalmic Perindopril Aceon Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Ophthalmic Phenobarbital Fidoquel Decreased exposure of diclofenac Details Diclofenac Ophthalmic Pindolol Visken® Reduced antihypertensive effect Details Diclofenac Ophthalmic Pralatrexate Increased pralatrexate exposure Details Diclofenac Ophthalmic Propranolol Hemangeol Reduced antihypertensive effect Details Diclofenac Ophthalmic Quinapril Accupril Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Ophthalmic Ramipril Altace Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Ophthalmic Rifampin Rifadin Decreased exposure of diclofenac Details Diclofenac Ophthalmic Rifapentine Priftin Decreased exposure of diclofenac Details Diclofenac Ophthalmic Secobarbital Decreased exposure of diclofenac Details Diclofenac Ophthalmic Sotalol Betapace Reduced antihypertensive effect Details Diclofenac Ophthalmic Spirapril Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Ophthalmic St John's Wort Decreased exposure of diclofenac Details Diclofenac Ophthalmic Sulfaphenazole Increased exposure of diclofenac Details Diclofenac Ophthalmic Telmisartan Micardis Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Ophthalmic Timolol Betimol Reduced antihypertensive effect Details Diclofenac Ophthalmic Trandolapril Mavik® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Ophthalmic Valsartan Diovan Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Ophthalmic Voriconazole Vfend Increased exposure of diclofenac Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.