Diclofenac Ophthalmic

268 interactions 703 cited references
Also sold as: Voltaren® Eye Drops
About Diclofenac Ophthalmic

Diclofenac ophthalmic solution is used to treat eye pain, redness, and swelling in patients who are recovering from cataract surgery (procedure to treat clouding of the lens in the eye). Diclofenac ophthalmic solution is also used to temporarily relieve eye pain and sensitivity to light in patients who are recovering f… Read the full Diclofenac Ophthalmic drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Moderate

Diclofenac Ophthalmic Acebutolol Sectral® Reduced antihypertensive effect Details Diclofenac Ophthalmic Amiodarone Nexterone Increased exposure of diclofenac Details Diclofenac Ophthalmic Aprepitant Aponvie Decreased exposure of diclofenac Details Diclofenac Ophthalmic Atenolol Tenormin Reduced antihypertensive effect Details Diclofenac Ophthalmic Azilsartan Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Ophthalmic Azilsartan Medoxomil Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Ophthalmic Benazepril Lotensin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Ophthalmic Betaxolol Betoptic S Reduced antihypertensive effect Details Diclofenac Ophthalmic Bisoprolol Zebeta® Reduced antihypertensive effect Details Diclofenac Ophthalmic Bosentan Decreased exposure of diclofenac Details Diclofenac Ophthalmic Candesartan Atacand Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Ophthalmic Captopril Capoten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Ophthalmic Carbamazepine Carbatrol Decreased exposure of diclofenac Details Diclofenac Ophthalmic Carteolol Reduced antihypertensive effect Details Diclofenac Ophthalmic Carvedilol Coreg Reduced antihypertensive effect Details Diclofenac Ophthalmic Celiprolol Reduced antihypertensive effect Details Diclofenac Ophthalmic Cholestyramine Prevalite Decreased diclofenac bioavailability Details Diclofenac Ophthalmic Ciprofloxacin An increased risk of convulsions Details Diclofenac Ophthalmic Colestipol Colestid Decreased diclofenac bioavailability Details Diclofenac Ophthalmic Desmopressin DDAVP Increased risk of water intoxication with hyponatremia Details Diclofenac Ophthalmic Enalapril Epaned Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Ophthalmic Enalaprilat Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Ophthalmic Entacapone Comtan Increased diclofenac exposure Details Diclofenac Ophthalmic Enzalutamide Xtandi Decreased exposure of diclofenac Details Diclofenac Ophthalmic Eprosartan Teveten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Ophthalmic Esmolol Brevibloc Reduced antihypertensive effect Details Diclofenac Ophthalmic Fluconazole Diflucan Increased exposure of diclofenac Details Diclofenac Ophthalmic Fosaprepitant Emend Injection Decreased exposure of diclofenac Details Diclofenac Ophthalmic Fosinopril Monopril® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Ophthalmic Ginkgo An increased risk of bleeding Details Diclofenac Ophthalmic Irbesartan Avapro Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Ophthalmic Labetalol Normodyne® Reduced antihypertensive effect Details Diclofenac Ophthalmic Levobunolol Betagan Reduced antihypertensive effect Details Diclofenac Ophthalmic Levofloxacin Levaquin An increased risk of seizures Details Diclofenac Ophthalmic Lisinopril Prinivil Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Ophthalmic L-Methylfolate Decreased l-methylfolate efficacy Details Diclofenac Ophthalmic Losartan Arbli Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Ophthalmic Ma Huang Increased risk of developing gastric mucosal lesions Details Diclofenac Ophthalmic Mavacamten Camzyos Reduced CYP2C9 substrate exposure and reduced efficacy of CYP2C9 substrate Details Diclofenac Ophthalmic Metipranolol Reduced antihypertensive effect Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.