Diclofenac Transdermal Patch

268 interactions 703 cited references
Also sold as: Flector Flector® Patch Licart Licart ® Topical System Xiclo
About Diclofenac Transdermal Patch

Transdermal diclofenac is used to treat short-term pain due to minor strains, sprains, and bruises in adults and children 6 years of age and older. Diclofenac is in a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by stopping the body's production of a substance that causes pain. Read the full Diclofenac Transdermal Patch drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Moderate

Diclofenac Transdermal Patch Mifepristone Korlym Increased NSAID exposure Details Diclofenac Transdermal Patch Moexipril Univasc® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Transdermal Patch Nadolol Corgard Reduced antihypertensive effect Details Diclofenac Transdermal Patch Nebivolol Bystolic Reduced antihypertensive effect Details Diclofenac Transdermal Patch Norfloxacin An increased risk of seizures Details Diclofenac Transdermal Patch Ofloxacin Floxin® An increased risk of seizures Details Diclofenac Transdermal Patch Olmesartan Benicar Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Transdermal Patch Oxprenolol Reduced antihypertensive effect Details Diclofenac Transdermal Patch Penbutolol Levatol® Reduced antihypertensive effect Details Diclofenac Transdermal Patch Perindopril Aceon Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Transdermal Patch Phenobarbital Fidoquel Decreased exposure of diclofenac Details Diclofenac Transdermal Patch Pindolol Visken® Reduced antihypertensive effect Details Diclofenac Transdermal Patch Pralatrexate Increased pralatrexate exposure Details Diclofenac Transdermal Patch Propranolol Hemangeol Reduced antihypertensive effect Details Diclofenac Transdermal Patch Quinapril Accupril Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Transdermal Patch Ramipril Altace Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Transdermal Patch Rifampin Rifadin Decreased exposure of diclofenac Details Diclofenac Transdermal Patch Rifapentine Priftin Decreased exposure of diclofenac Details Diclofenac Transdermal Patch Secobarbital Decreased exposure of diclofenac Details Diclofenac Transdermal Patch Sotalol Betapace Reduced antihypertensive effect Details Diclofenac Transdermal Patch Spirapril Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Transdermal Patch St John's Wort Decreased exposure of diclofenac Details Diclofenac Transdermal Patch Sulfaphenazole Increased exposure of diclofenac Details Diclofenac Transdermal Patch Telmisartan Micardis Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Transdermal Patch Timolol Betimol Reduced antihypertensive effect Details Diclofenac Transdermal Patch Trandolapril Mavik® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Transdermal Patch Valsartan Diovan Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Transdermal Patch Voriconazole Vfend Increased exposure of diclofenac Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.