Diclofenac Transdermal Patch

268 interactions 703 cited references

Also sold as: Flector Flector® Patch Licart Licart ® Topical System Xiclo

About Diclofenac Transdermal Patch

Transdermal diclofenac is used to treat short-term pain due to minor strains, sprains, and bruises in adults and children 6 years of age and older. Diclofenac is in a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by stopping the body's production of a substance that causes pain. Read the full Diclofenac Transdermal Patch drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Xipamide Fluorouracil Flufenamic Acid Floctafenine Feverfew

1 Contraindicated 197 Major 70 Moderate

All (268) Contraindicated (1) Major (197) Moderate (70)

Moderate

Diclofenac Transdermal Patch Aprepitant Aponvie Decreased exposure of diclofenac Details Diclofenac Transdermal Patch Atenolol Tenormin Reduced antihypertensive effect Details Diclofenac Transdermal Patch Azilsartan Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Transdermal Patch Azilsartan Medoxomil Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Transdermal Patch Benazepril Lotensin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Transdermal Patch Betaxolol Betoptic S Reduced antihypertensive effect Details Diclofenac Transdermal Patch Bisoprolol Zebeta® Reduced antihypertensive effect Details Diclofenac Transdermal Patch Bosentan Decreased exposure of diclofenac Details Diclofenac Transdermal Patch Candesartan Atacand Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Transdermal Patch Captopril Capoten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Transdermal Patch Carbamazepine Carbatrol Decreased exposure of diclofenac Details Diclofenac Transdermal Patch Carteolol Reduced antihypertensive effect Details Diclofenac Transdermal Patch Carvedilol Coreg Reduced antihypertensive effect Details Diclofenac Transdermal Patch Celiprolol Reduced antihypertensive effect Details Diclofenac Transdermal Patch Cholestyramine Prevalite Decreased diclofenac bioavailability Details Diclofenac Transdermal Patch Ciprofloxacin An increased risk of convulsions Details Diclofenac Transdermal Patch Colestipol Colestid Decreased diclofenac bioavailability Details Diclofenac Transdermal Patch Desmopressin DDAVP Increased risk of water intoxication with hyponatremia Details Diclofenac Transdermal Patch Enalapril Epaned Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Transdermal Patch Enalaprilat Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Transdermal Patch Entacapone Comtan Increased diclofenac exposure Details Diclofenac Transdermal Patch Enzalutamide Xtandi Decreased exposure of diclofenac Details Diclofenac Transdermal Patch Eprosartan Teveten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Transdermal Patch Esmolol Brevibloc Reduced antihypertensive effect Details Diclofenac Transdermal Patch Fluconazole Diflucan Increased exposure of diclofenac Details Diclofenac Transdermal Patch Fosaprepitant Emend Injection Decreased exposure of diclofenac Details Diclofenac Transdermal Patch Fosinopril Monopril® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Transdermal Patch Ginkgo An increased risk of bleeding Details Diclofenac Transdermal Patch Irbesartan Avapro Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Transdermal Patch Labetalol Normodyne® Reduced antihypertensive effect Details Diclofenac Transdermal Patch Levobunolol Betagan Reduced antihypertensive effect Details Diclofenac Transdermal Patch Levofloxacin Levaquin An increased risk of seizures Details Diclofenac Transdermal Patch Lisinopril Prinivil Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Transdermal Patch L-Methylfolate Decreased l-methylfolate efficacy Details Diclofenac Transdermal Patch Losartan Arbli Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Transdermal Patch Ma Huang Increased risk of developing gastric mucosal lesions Details Diclofenac Transdermal Patch Mavacamten Camzyos Reduced CYP2C9 substrate exposure and reduced efficacy of CYP2C9 substrate Details Diclofenac Transdermal Patch Metipranolol Reduced antihypertensive effect Details Diclofenac Transdermal Patch Metoprolol Kapspargo Reduced antihypertensive effect Details Diclofenac Transdermal Patch Miconazole Aloe Vesta Antifungal Increased exposure of diclofenac Details

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