Diclofenac Transdermal Patch

268 interactions 703 cited references

Also sold as: Flector Flector® Patch Licart Licart ® Topical System Xiclo

About Diclofenac Transdermal Patch

Transdermal diclofenac is used to treat short-term pain due to minor strains, sprains, and bruises in adults and children 6 years of age and older. Diclofenac is in a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by stopping the body's production of a substance that causes pain. Read the full Diclofenac Transdermal Patch drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Xipamide Fluorouracil Flufenamic Acid Floctafenine Feverfew

1 Contraindicated 197 Major 70 Moderate

All (268) Contraindicated (1) Major (197) Moderate (70)

Major

Diclofenac Transdermal Patch Selexipag Uptravi An increased risk of bleeding Details Diclofenac Transdermal Patch Sertraline An increased risk of bleeding Details Diclofenac Transdermal Patch Sibutramine An increased risk of bleeding Details Diclofenac Transdermal Patch Sodium Salicylate Increased risk of bleeding Details Diclofenac Transdermal Patch Sparsentan Filspari An increased risk of kidney injury, reduced CYP2C9 substrate exposure and reduced CYP2C9 substrate efficacy Details Diclofenac Transdermal Patch Spironolactone Aldactone Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Diclofenac Transdermal Patch Sulfasalazine Azulfidine Increased risk of bleeding Details Diclofenac Transdermal Patch Sulfinpyrazone An increased risk of bleeding Details Diclofenac Transdermal Patch Sulindac Clinoril® Increased risk of bleeding Details Diclofenac Transdermal Patch Sulodexide An increased risk of bleeding Details Diclofenac Transdermal Patch Tacrolimus Astagraf Acute renal failure Details Diclofenac Transdermal Patch Tegafur Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Diclofenac Transdermal Patch Tenofovir Alafenamide Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details Diclofenac Transdermal Patch Tenofovir Disoproxil Fumarate Increased risk of acute renal failure Details Diclofenac Transdermal Patch Tenoxicam Increased risk of bleeding Details Diclofenac Transdermal Patch Tianeptine An increased risk of bleeding Details Diclofenac Transdermal Patch Tiaprofenic Acid Increased risk of bleeding Details Diclofenac Transdermal Patch Ticagrelor Brilinta An increased risk of bleeding Details Diclofenac Transdermal Patch Ticlopidine Ticlid® An increased risk of bleeding Details Diclofenac Transdermal Patch Tinzaparin An increased risk of bleeding Details Diclofenac Transdermal Patch Tirofiban An increased risk of bleeding Details Diclofenac Transdermal Patch Tolfenamic Acid Increased risk of bleeding Details Diclofenac Transdermal Patch Tolmetin Tolectin 600 Increased risk of bleeding Details Diclofenac Transdermal Patch Torsemide Soaanz Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Transdermal Patch Trazodone Raldesy An increased risk of bleeding Details Diclofenac Transdermal Patch Treprostinil Orenitram An increased risk of bleeding Details Diclofenac Transdermal Patch Triamterene Dyrenium Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Diclofenac Transdermal Patch Trichlormethiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Transdermal Patch Trimipramine An increased risk of bleeding Details Diclofenac Transdermal Patch Trolamine Salicylate Increased risk of bleeding Details Diclofenac Transdermal Patch Upadacitinib Rinvoq Increased risk of gastrointestinal perforations Details Diclofenac Transdermal Patch Valdecoxib Increased risk of bleeding Details Diclofenac Transdermal Patch Venlafaxine An increased risk of bleeding Details Diclofenac Transdermal Patch Vilazodone Viibryd An increased risk of bleeding Details Diclofenac Transdermal Patch Vorapaxar Zontivity An increased risk of bleeding Details Diclofenac Transdermal Patch Vortioxetine Trintellix An increased risk of bleeding Details Diclofenac Transdermal Patch Warfarin Coumadin An increased risk of bleeding Details Diclofenac Transdermal Patch Xipamide Reduced diuretic effectiveness and possible nephrotoxicity Details

Moderate

Diclofenac Transdermal Patch Acebutolol Sectral® Reduced antihypertensive effect Details Diclofenac Transdermal Patch Amiodarone Nexterone Increased exposure of diclofenac Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.