Diclofenac Transdermal Patch and Trazodone: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Trazodone
Diclofenac Transdermal Patch
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of bleeding
Interaction Deep Dive
Concomitant use of traZODone with other drugs that affect hemostasis such as NSAIDs may increase bleeding risk. Drugs that interfere with serotonin reuptake, including traZODone, increase risk of bleeding events. Bleeding events associated with serotonin reuptake inhibitors have included ecchymosis, hematoma, epistaxis, petechiae, gastrointestinal bleeding, and life-threatening hemorrhage1.
Why it happens (mechanism)
Additive effects on hemostasis; altered anticoagulant effects
Literature reports
1 report — tap to read
a) Case reports and epidemiological studies (case-control and cohort design) have demonstrated an association between use of drugs that interfere with serotonin reuptake (including traZODone) and the occurrence of gastrointestinal bleeding. Bleeding events related to drugs that interfere with serotonin reuptake have ranged from ecchymosis, hematoma, epistaxis, and petechiae to life-threatening hemorrhages 1.
Common questions
Can I take Diclofenac Transdermal Patch and Trazodone together?
An increased risk of bleeding Always confirm with your pharmacist or prescriber before making any change.
How serious is the Diclofenac Transdermal Patch and Trazodone interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Diclofenac Transdermal Patch or Trazodone need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: Trazodone HCl oral tablets, trazodone HCl oral tablets. Rising Pharma Holdings, Inc (per DailyMed), East Brunswick, NJ, 2025. DailyMed
Keep reading about Trazodone
Keep reading about Diclofenac Transdermal Patch
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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