Diethylpropion

21 interactions 71 cited references
Also sold as: Tenuate Tenuate® Tenuate® Dospan Tepanil®
About Diethylpropion

Diethylpropion decreases appetite. It is used on a short-term basis (a few weeks), in combination with diet, to help you lose weight. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Read the full Diethylpropion drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Brofaromine Clorgyline Furazolidone Linezolid Injection Iproniazid Isocarboxazid
18 Contraindicated 2 Major 1 Moderate
All (21) Contraindicated (18) Major (2) Moderate (1)

Contraindicated

Diethylpropion Brofaromine Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Diethylpropion Clorgyline Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Diethylpropion Furazolidone Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Diethylpropion Iproniazid Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Diethylpropion Isocarboxazid Marplan Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Diethylpropion Lazabemide Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Diethylpropion Linezolid Zyvox Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Diethylpropion Moclobemide Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Diethylpropion Nialamide Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Diethylpropion Pargyline Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Diethylpropion Phenelzine Nardil Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Diethylpropion Procarbazine Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Diethylpropion Rasagiline Azilect Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Diethylpropion Selegiline Anipryl Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Diethylpropion Sibutramine An increased risk of hypertension and tachycardia Details Diethylpropion Toloxatone Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Diethylpropion Tranylcypromine Parnate Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Diethylpropion Linezolid Injection Zyvox Hypertensive crisis (headache, hyperpyrexia, hypertension) Details

Major

Diethylpropion Iobenguane I 131 Azedra Inaccurate dosimetry calculations or reduced efficacy Details Diethylpropion Venlafaxine An increase risk of adverse events Details

Moderate

Diethylpropion Guanethidine Decreased guanethidine effectiveness Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.