Diflunisal

100 interactions 6 explained in plain English
Also sold as: Dolobid
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ketorolac Injection Ketorolac Nasal Spray Ketorolac Ophthalmic Cyclosporine Ophthalmic Dabigatran Etexilate
4 Contraindicated 61 Major 35 Moderate
All (100) Contraindicated (4) Major (61) Moderate (35)

Major

Diflunisal Heparin Injection Lipo-Hepin® An increased risk of bleeding Details Diflunisal Hydrocortisone Ala-Cort Increased risk of gastrointestinal ulcer or bleeding Details Diflunisal Hydrocortisone Injection A-Hydrocort® Increased risk of gastrointestinal ulcer or bleeding Details Diflunisal Ibuprofen Addaprin Increased risk of bleeding Details Diflunisal Iloprost Aurlumyn An increased risk of bleeding Details Diflunisal Ketoprofen Actron® Increased risk of bleeding Details Diflunisal Lithium Carbonate Lithobid Increased lithium exposure and an increased risk of lithium toxicity Details Diflunisal Meclofenamate Meclodium® Increased risk of bleeding Details Diflunisal Mefenamic Acid Ponstel® Increased risk of bleeding Details Diflunisal Meloxicam Alloxate Increased risk of bleeding Details Diflunisal Meloxicam Injection Alloxate Increased risk of bleeding Details Diflunisal Melphalan Alkeran An increased risk of bleeding Details Diflunisal Melphalan Injection Alkeran An increased risk of bleeding Details Diflunisal Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Diflunisal Mesalamine Apriso Increased risk of bleeding Details Diflunisal Mesalamine Rectal Canasa Increased risk of bleeding Details Diflunisal Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate toxicity or methotrexate-related severe adverse reactions, redu... Details Diflunisal Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate toxicity or methotrexate-related severe adverse reactions, redu... Details Diflunisal Nabumetone Relafen Increased risk of bleeding Details Diflunisal Naproxen Aleve Increased risk of bleeding Details Diflunisal Pemetrexed Injection Alimta Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.