Diflunisal
100 interactions 6 explained in plain English
Also sold as:
Dolobid
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Ketorolac
Ketorolac Injection
Ketorolac Nasal Spray
Ketorolac Ophthalmic
Cyclosporine Ophthalmic
Dabigatran Etexilate
Contraindicated
Diflunisal Ketorolac Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Diflunisal Ketorolac Injection Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Diflunisal Ketorolac Nasal Spray Sprix Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Diflunisal Ketorolac Ophthalmic Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) DetailsMajor
Diflunisal Amitriptyline Elavil Explained An increased risk of bleeding Details Diflunisal Sertraline Explained An increased risk of bleeding Details Diflunisal Apixaban Eliquis Explained An increased risk of bleeding Details Diflunisal Aspirin Acuprin® An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Diflunisal Aspirin Rectal Aspirin An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Diflunisal Azathioprine Azasan An increased risk of hepatotoxicity Details Diflunisal Betrixaban Bevyxxa® An increased risk of bleeding Details Diflunisal Anagrelide Agrylin An increased risk of bleeding Details Diflunisal Bromfenac Ophthalmic Bromday® Increased risk of bleeding Details Diflunisal Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Diflunisal Budesonide Nasal Spray Rhinocort Increased risk of gastrointestinal ulcer or bleeding Details Diflunisal Budesonide Oral Inhalation Pulmicort Increased risk of gastrointestinal ulcer or bleeding Details Diflunisal Clopidogrel Plavix An increased risk of bleeding Details Diflunisal Cyclosporine Injection Atopica An increased risk of cycloSPORINE nephrotoxicity Details Diflunisal Cyclosporine Ophthalmic Cequa An increased risk of cycloSPORINE nephrotoxicity Details Diflunisal Dabigatran Pradaxa® An increased risk of bleeding Details Diflunisal Dabigatran Etexilate An increased risk of bleeding Details Diflunisal Dalteparin Injection Fragmin An increased risk of bleeding Details Diflunisal Deflazacort Emflaza Increased risk of gastrointestinal ulcer or bleeding Details Diflunisal Dexamethasone Injection Decadron Increased risk of gastrointestinal ulcer or bleeding Details Diflunisal Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased risk of gastrointestinal ulcer or bleeding Details Diflunisal Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of bleeding Details Diflunisal Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of bleeding Details Diflunisal Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of bleeding Details Diflunisal Diclofenac Transdermal Patch Flector Increased risk of bleeding Details Diflunisal Digoxin Cardoxin® Increased digoxin exposure and prolonged half-life of digoxin Details Diflunisal Dipyridamole Permole® An increased risk of bleeding Details Diflunisal Edoxaban Savaysa An increased risk of bleeding Details Diflunisal Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Diflunisal Enoxaparin Lovenox An increased risk of bleeding Details Diflunisal Enoxaparin Injection Lovenox An increased risk of bleeding Details Diflunisal Epoprostenol Flolan An increased risk of bleeding Details Diflunisal Etodolac Lodine Increased risk of bleeding Details Diflunisal Fenoprofen Fenopron Increased risk of bleeding Details Diflunisal Flurbiprofen Ansaid Increased risk of bleeding Details Diflunisal Flurbiprofen Ophthalmic Ocufen Increased risk of bleeding DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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