Diflunisal

100 interactions 6 explained in plain English
Also sold as: Dolobid
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Diflunisal Fondaparinux Arixtra An increased risk of bleeding Details Diflunisal Fondaparinux Injection Arixtra An increased risk of bleeding Details Diflunisal Furosemide Injection Disal An increased risk of salicylate toxicity and reduced diuretic effectiveness and possible nephrotoxicity Details Diflunisal Heparin An increased risk of bleeding Details Diflunisal Heparin Injection Lipo-Hepin® An increased risk of bleeding Details Diflunisal Hydrocortisone Ala-Cort Increased risk of gastrointestinal ulcer or bleeding Details Diflunisal Hydrocortisone Injection A-Hydrocort® Increased risk of gastrointestinal ulcer or bleeding Details Diflunisal Ibuprofen Addaprin Increased risk of bleeding Details Diflunisal Iloprost Aurlumyn An increased risk of bleeding Details Diflunisal Ketoprofen Actron® Increased risk of bleeding Details Diflunisal Lithium Carbonate Lithobid Increased lithium exposure and an increased risk of lithium toxicity Details Diflunisal Meclofenamate Meclodium® Increased risk of bleeding Details Diflunisal Mefenamic Acid Ponstel® Increased risk of bleeding Details Diflunisal Meloxicam Alloxate Increased risk of bleeding Details Diflunisal Meloxicam Injection Alloxate Increased risk of bleeding Details Diflunisal Melphalan Alkeran An increased risk of bleeding Details Diflunisal Melphalan Injection Alkeran An increased risk of bleeding Details Diflunisal Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Diflunisal Mesalamine Apriso Increased risk of bleeding Details Diflunisal Mesalamine Rectal Canasa Increased risk of bleeding Details Diflunisal Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate toxicity or methotrexate-related severe adverse reactions, redu... Details Diflunisal Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate toxicity or methotrexate-related severe adverse reactions, redu... Details Diflunisal Nabumetone Relafen Increased risk of bleeding Details Diflunisal Naproxen Aleve Increased risk of bleeding Details Diflunisal Pemetrexed Injection Alimta Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details

Moderate

Diflunisal Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of acetaminophen toxicity (hepatotoxicity) Details Diflunisal Lisinopril Prinivil Explained Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diflunisal Acetaminophen Acephen An increased risk of acetaminophen toxicity (hepatotoxicity) Details Diflunisal Acetaminophen Injection Acephen An increased risk of acetaminophen toxicity (hepatotoxicity) Details Diflunisal Acetaminophen Rectal Acephen An increased risk of acetaminophen toxicity (hepatotoxicity) Details Diflunisal Atenolol Tenormin Explained Reduced antihypertensive effect Details Diflunisal Acebutolol Sectral® Reduced antihypertensive effect Details Diflunisal Benazepril Lotensin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diflunisal Azilsartan Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diflunisal Betaxolol Betoptic S Reduced antihypertensive effect Details Diflunisal Betaxolol Ophthalmic Betoptic® Reduced antihypertensive effect Details Diflunisal Bisoprolol Zebeta® Reduced antihypertensive effect Details Diflunisal Captopril Capoten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diflunisal Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Diflunisal Enalapril Epaned Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.