Diflunisal

100 interactions 6 explained in plain English
Also sold as: Dolobid
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ketorolac Injection Ketorolac Nasal Spray Ketorolac Ophthalmic Cyclosporine Ophthalmic Dabigatran Etexilate
4 Contraindicated 61 Major 35 Moderate
All (100) Contraindicated (4) Major (61) Moderate (35)

Moderate

Diflunisal Eprosartan Teveten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diflunisal Esmolol Brevibloc Reduced antihypertensive effect Details Diflunisal Fosinopril Monopril® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diflunisal Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Increased risk of hypoglycemia Details Diflunisal Insulin Detemir (Rdna Origin) Injection Levemir Increased risk of hypoglycemia Details Diflunisal Insulin Glulisine (Rdna Origin) Injection Apidra Increased risk of hypoglycemia Details Diflunisal Irbesartan Avapro Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diflunisal Labetalol Normodyne® Reduced antihypertensive effect Details Diflunisal Levobunolol Ophthalmic AKBeta® Reduced antihypertensive effect Details Diflunisal Levofloxacin Levaquin An increased risk of seizures Details Diflunisal Levofloxacin Injection Levaquin An increased risk of seizures Details Diflunisal Losartan Arbli Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diflunisal Moexipril Univasc® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diflunisal Nadolol Corgard Reduced antihypertensive effect Details Diflunisal Nebivolol Bystolic Reduced antihypertensive effect Details Diflunisal Ofloxacin Floxin® An increased risk of seizures Details Diflunisal Ofloxacin Ophthalmic Ocuflox An increased risk of seizures Details Diflunisal Ofloxacin Otic Floxin® Otic An increased risk of seizures Details Diflunisal Penbutolol Levatol® Reduced antihypertensive effect Details Diflunisal Perindopril Aceon Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.