Docetaxel and Belumosudil: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Belumosudil
Docetaxel
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased OATP1B1 substrate exposure
Interaction Deep Dive
Avoid concomitant administration of belumosudil (OATP1B1 inhibitor) and a OATP1B1 substrate with narrow therapeutic index (NTI) where minimal concentration changes may lead to serious toxicities. If coadministration cannot be avoided, decrease OATP1B1 substrate dosage as needed. In a drug interaction study, coadministration of belumosudil increased rosuvastatin (OATP1B1 and BCRP substrate) Cmax and AUC by 3.6-fold and 4.6-fold respectively1.
Why it happens (mechanism)
Inhibition of OATP1B1-mediated efflux transport by belumosudil
Literature reports
1 report — tap to read
a) In a drug interaction study, coadministration of belumosudil increased rosuvastatin (OATP1B1 and BCRP substrate) Cmax and AUC by 3.6-fold and 4.6-fold respectively 1.
Common questions
Can I take Docetaxel and Belumosudil together?
Increased OATP1B1 substrate exposure Always confirm with your pharmacist or prescriber before making any change.
How serious is the Docetaxel and Belumosudil interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Docetaxel or Belumosudil need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: REZUROCK(R) oral tablets, belumosudil oral tablets. Kadmon Pharmaceuticals LLC (per FDA), Bridgewater, NJ, 2024. DailyMed
Keep reading about Belumosudil
Keep reading about Docetaxel
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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