Belumosudil

88 interactions 69 explained in plain English 282 cited references

Also sold as: Rezurock Rezurock®

About Belumosudil

Belumosudil is used to treat graft versus host disease (GVHD; a complication of hematopoietic stem-cell transplant [HSCT; a procedure that replaces diseased bone marrow with healthy bone marrow]) in adults and children 12 years of age and older who were treated unsuccessfully with at least two other treatments. Belumos… Read the full Belumosudil drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 12, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Measles Virus Vaccine, Live Mumps Virus Vaccine, Live Rubella Virus Vaccine, Live Smallpox Monkeypox Vaccine Typhoid Vaccine Varicella Virus Vaccine, Live

10 Contraindicated 70 Major 8 Moderate

All (88) Contraindicated (10) Major (70) Moderate (8)

Contraindicated

Belumosudil Bacillus Of Calmette And Guerin Vaccine, Live Explained An increased risk of infection by the live vaccine Details Belumosudil Dengue Tetravalent Vaccine, Live Explained An increased risk of infection by the live vaccine Details Belumosudil Ensitrelvir Explained Increased CYP3A substrates exposure and an increased risk of CYP3A substrates-related adverse effects Details Belumosudil Measles Virus Vaccine, Live Explained An increased risk of infection by the live vaccine Details Belumosudil Mumps Virus Vaccine, Live Explained An increased risk of infection by the live vaccine Details Belumosudil Rubella Virus Vaccine, Live Explained An increased risk of infection by the live vaccine Details Belumosudil Smallpox Monkeypox Vaccine Explained An increased risk of infection by the live vaccine Details Belumosudil Typhoid Vaccine Typhim VI® Explained An increased risk of infection by the live vaccine Details Belumosudil Varicella Virus Vaccine, Live Explained An increased risk of infection by the live vaccine Details Belumosudil Yellow Fever Vaccine Stamaril Explained An increased risk of infection by the live vaccine Details

Major

Belumosudil Omeprazole Gastrobim Explained Reduced belumosudil exposure Details Belumosudil Colchicine Colcrys Explained Increased P-gp substrate exposure Details Belumosudil Adenovirus Vaccine Type 4, Live Explained An increased risk of infection by the live vaccine Details Belumosudil Adenovirus Vaccine Type 7, Live Explained An increased risk of infection by the live vaccine Details Belumosudil Alfentanil Explained Increased ALfentanil exposure and an increased risk of respiratory depression Details Belumosudil Apalutamide Erleada Explained Reduced belumosudil exposure and reduced efficacy of belumosudil Details Belumosudil Artemether Explained Increased artemether/lumefantrine exposure, an increased risk of QT prolongation, reduced CYP3A4 substrate exposure and reduced ef... Details Belumosudil Avacopan Tavneos Explained Increased CYP3A4 substrate exposure Details Belumosudil Axitinib Inlyta Increased OATP1B1 substrate exposure Details Belumosudil Carbamazepine Carbatrol Explained Reduced belumosudil exposure and reduced efficacy of belumosudil Details Belumosudil Cholera Vaccine Ipol Explained An increased risk of infection by the live vaccine Details Belumosudil Clarithromycin Biaxin Explained Increased exposure of CYP3A4 substrate and risk for toxicity Details Belumosudil Conivaptan Vaprisol Explained Increased CYP3A substrate exposure Details Belumosudil Cyclosporine Atopica Explained Increased P-gp substrate exposure Details Belumosudil Dexlansoprazole Dexilant Reduced belumosudil exposure Details Belumosudil Digoxin Cardoxin® Increased P-gp substrate exposure Details Belumosudil Docetaxel Beizray Increased OATP1B1 substrate exposure Details Belumosudil Ebola Zaire Vaccine, Live Explained An increased risk of infection by the live vaccine Details Belumosudil Enzalutamide Xtandi Explained Reduced belumosudil exposure and reduced efficacy of belumosudil Details Belumosudil Erythromycin Erythrocin Stearate Explained Increased CYP3A4 substrate exposure and an increased risk of CYP3A4-substrate-related adverse effects Details Belumosudil Esomeprazole Nexium Reduced belumosudil exposure Details Belumosudil Everolimus Afinitor Increased P-gp substrate exposure Details Belumosudil Fedratinib Inrebic Explained Increased CYP3A4 substrate exposure Details Belumosudil Fexinidazole Explained An increased CYP3A4 substrate exposure Details Belumosudil Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Belumosudil Fosphenytoin Cerebyx Explained Reduced belumosudil exposure and reduced efficacy of belumosudil Details Belumosudil Glyburide DiaBeta® Explained Increased OATP1B1 substrate exposure Details Belumosudil Haloperidol Explained Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Belumosudil Influenza Virus Vaccine, Live Explained An increased risk of infection by the live vaccine Details Belumosudil Itraconazole Sporanox Explained Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse effects Details

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