Esomeprazole and Belumosudil: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Belumosudil
Esomeprazole
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Reduced belumosudil exposure
Interaction Deep Dive
Coadministration of belumosudil and a proton pump inhibitor may decrease belumosudil exposure, which may reduce the efficacy of belumosudil. In drug interaction studies in healthy subjects, coadministration of belumosudil with rabeprazole and with omeprazole (proton pump inhibitors) decreased belumosudil Cmax by 87% and 68% and AUC by 80% and 47%, respectively. If belumosudil and a a proton pump inhibitor are coadministered, increase the dosage of belumosudil to 200 mg twice daily1.
Why it happens (mechanism)
Increased gastric pH by proton pump inhibitors
Literature reports
2 reports — tap to read
a) In a drug interaction study in healthy subjects, coadministration of belumosudil with rabeprazole (a proton pump inhibitor) decreased belumosudil Cmax by 87% and AUC by 80%.1.
b) In a drug interaction study in healthy subjects, coadministration of belumosudil with omeprazole (a proton pump inhibitor) decreased belumosudil Cmax by 68% and AUC by 47%.1.
Common questions
Can I take Esomeprazole and Belumosudil together?
Reduced belumosudil exposure Always confirm with your pharmacist or prescriber before making any change.
How serious is the Esomeprazole and Belumosudil interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Esomeprazole or Belumosudil need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: REZUROCK(R) oral tablets, belumosudil oral tablets. Kadmon Pharmaceuticals LLC (per FDA), Bridgewater, NJ, 2024. DailyMed
Keep reading about Belumosudil
Keep reading about Esomeprazole
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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