Dofetilide

454 interactions 653 cited references

Also sold as: Tikosyn Tikosyn®

About Dofetilide

Dofetilide is an antiarrhythmic medication used to treat irregular heartbeats like atrial fibrillation or atrial flutter. Read the full Dofetilide drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Sulfamethoxazole Cisapride Bictegravir Cimetidine Sparfloxacin Saquinavir

33 Contraindicated 288 Major 131 Moderate 2 Minor

All (454) Contraindicated (33) Major (288) Moderate (131) Minor (2)

Major

Dofetilide Abametapir Increased exposure of CYP3A4 substrate Details Dofetilide Amitriptyline Elavil An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dofetilide Sertraline An increased risk of QT interval prolongation Details Dofetilide Buprenorphine Belbuca An increased risk of QT interval prolongation Details Dofetilide Relugolix Orgovyx Increased risk of QT interval prolongation Details Dofetilide Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Dofetilide Arsenic Trioxide Trisenox Cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dofetilide Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Dofetilide Arsenic Trioxide Injection Trisenox Cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dofetilide Asciminib Scemblix Increased CYP3A4 exposure and an increased risk of CYP3A4-related adverse reactions Details Dofetilide Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Dofetilide Azithromycin AzaSite An increased risk of cardiotoxicity (QT interval prolongation, torsades de pointes, cardiac arrest) Details Dofetilide Alfuzosin UroXatral An increased risk of QT interval prolongation Details Dofetilide Anagrelide Agrylin Increased risk of QT interval prolongation Details Dofetilide Arimoclomol Increased OCT2 substrate exposure Details Dofetilide Bedaquiline Sirturo Increased risk of QT interval prolongation Details Dofetilide Capmatinib Tabrecta Increased exposure of MATE1 and MATE2K substrates and risk of increased adverse reactions Details Dofetilide Chloroquine Aralen® Cardiotoxicity (QT interval prolongation, torsades de pointes, cardiac arrest) Details Dofetilide Dasatinib Phyrago An increased risk of QT interval prolongation Details Dofetilide Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Dofetilide Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Dofetilide Digoxin Cardoxin® An increased risk of cardiotoxicity (torsade de pointes) Details Dofetilide Disopyramide Norpace An increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Dofetilide Acecainide An increased risk of cardiotoxicity (QT interval prolongation, torsades de pointes, cardiac arrest) Details Dofetilide Adagrasib Krazati Increased dofetilide exposure and an increased risk of QT interval prolongation, torsade de pointes, polymorphic ventricular tachy... Details Dofetilide Amiloride Increased dofetilide exposure Details Dofetilide Amiodarone Nexterone An increased risk of cardiotoxicity (QT interval prolongation, torsades de pointes, cardiac arrest) Details Dofetilide Amisulpride Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Dofetilide Amoxapine An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dofetilide Apalutamide Erleada Reduced CYP3A4 substrate exposure Details Dofetilide Apomorphine Apokyn An increased risk of QT interval prolongation Details Dofetilide Aprindine An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dofetilide Aripiprazole Abilify An increased risk of QT interval prolongation Details Dofetilide Aripiprazole Lauroxil Aristada An increased risk of QT interval prolongation Details Dofetilide Artemether An increased risk of QT interval prolongation, reduced dofetilide exposure and reduced efficacy of dofetilide Details Dofetilide Asenapine Saphris Increased risk of QT interval prolongation Details Dofetilide Astemizole Cardiotoxicity (QT interval prolongation, torsades de pointes, cardiac arrest) Details Dofetilide Atazanavir Reyataz An increased risk of QT interval prolongation Details Dofetilide Avacopan Tavneos Increased exposure to CYP3A4 substrate Details Dofetilide Azimilide An increased risk of cardiotoxicity (QT interval prolongation, torsades de pointes, cardiac arrest) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.