Dofetilide

Contraindicated

Dofetilide Cephalexin Keflet® Tablets Increased dofetilide exposure and an increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dofetilide Bepridil An increased risk of QT interval prolongation Details Dofetilide Bictegravir Increased dofetilide exposure and risk of serious and/or life-threatening adverse effects Details Dofetilide Cimetidine Tagamet Increased dofetilide exposure, an increased risk of QT interval prolongation, and an increased risk of torsades de pointes Details Dofetilide Cisapride Propulsid® Increased risk of QT interval prolongation Details Dofetilide Dolutegravir Juluca® (as a combination product containing dolutegravir, rilpivirine) Increased dofetilide exposure and risk of serious or life-threatening events Details Dofetilide Dronedarone Multaq Increased risk of QT interval prolongation Details Dofetilide Ensitrelvir Increased CYP3A substrates exposure and an increased risk of CYP3A substrates-related adverse effects Details Dofetilide Fingolimod Gilenya Increased risk of QT interval prolongation, bradycardia or heart block Details Dofetilide Fluconazole Diflucan Increased CYP3A4 substrate exposure and an increased risk of QT interval prolongation Details Dofetilide Hydrochlorothiazide Inzirqo Increased dofetilide exposure, an increased risk of hypokalemia or hypomagnesemia, an increased risk of QT interval prolongation,... Details Dofetilide Itraconazole Sporanox An increased risk of cardiotoxicity (QT interval prolongation, torsades de pointes, ventricular tachycardia, cardiac arrest, and/o... Details Dofetilide Ketoconazole Extina Increased dofetilide exposure, an increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) and an i... Details Dofetilide Levoketoconazole Recorlev Increased risk of QT interval prolongation and torsade de pointes, an increased CYP3A4 substrates exposure and an increased risk o... Details Dofetilide Levomethadyl An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dofetilide Megestrol Megace® Increased dofetilide exposure and an increased risk of QT interval prolongation, and an increased risk of torsades de pointes Details Dofetilide Mesoridazine An increased risk of QT interval prolongation Details Dofetilide Mifepristone Korlym Increased dofetilide exposure and an increased risk of QT interval prolongation Details Dofetilide Pimozide An increased risk of QT interval prolongation Details Dofetilide Piperaquine An increased risk of QT interval prolongation Details Dofetilide Posaconazole Noxafil Increased CYP3A4 substrate exposure and an increased risk of QT interval prolongation Details Dofetilide Prochlorperazine Increased dofetilide exposure, an increased risk of QT interval prolongation, and an increased risk of torsades de pointes Details Dofetilide Saquinavir Increased dofetilide exposure and increased risk of QT interval prolongation Details Dofetilide Sparfloxacin An increased risk of QT interval prolongation Details Dofetilide Sulfamethoxazole Sustain Increased dofetilide exposure and an increased risk of QT interval prolongation, and an increased risk of torsades de pointes Details Dofetilide Terfenadine An increased risk of QT interval prolongation Details Dofetilide Thioridazine An increased risk of QT interval prolongation Details Dofetilide Triamterene Dyrenium Increased dofetilide exposure and an increased risk of QT interval prolongation, and an increased risk of torsades de pointes Details Dofetilide Trimethoprim Primsol Increased dofetilide exposure and an increased risk of QT interval prolongation, and an increased risk of torsades de pointes Details Dofetilide Verapamil Calan Increased dofetilide exposure, an increased risk of QT interval prolongation, and an increased risk of torsades de pointes Details Dofetilide Vernakalant Increased risk of atrial flutter and other cardiovascular events Details Dofetilide Ziprasidone Geodon Increased risk of QT interval prolongation Details Dofetilide Ketoconazole Topical Extina® Foam Increased dofetilide exposure, an increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) and an i... Details

Major

Dofetilide Abametapir Increased exposure of CYP3A4 substrate Details Dofetilide Amitriptyline Elavil An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dofetilide Sertraline An increased risk of QT interval prolongation Details Dofetilide Buprenorphine Belbuca An increased risk of QT interval prolongation Details Dofetilide Relugolix Orgovyx Increased risk of QT interval prolongation Details Dofetilide Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Dofetilide Arsenic Trioxide Trisenox Cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details